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Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans.
Topalovic, Uros; Aghajan, Zahra M; Villaroman, Diane; Hiller, Sonja; Christov-Moore, Leonardo; Wishard, Tyler J; Stangl, Matthias; Hasulak, Nicholas R; Inman, Cory S; Fields, Tony A; Rao, Vikram R; Eliashiv, Dawn; Fried, Itzhak; Suthana, Nanthia.
Afiliación
  • Topalovic U; Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024,
  • Aghajan ZM; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
  • Villaroman D; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Hiller S; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
  • Christov-Moore L; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
  • Wishard TJ; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
  • Stangl M; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
  • Hasulak NR; NeuroPace, Mountain View, CA 94043, USA.
  • Inman CS; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
  • Fields TA; Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Rao VR; Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Eliashiv D; Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Fried I; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles,
  • Suthana N; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles,
Neuron ; 108(2): 322-334.e9, 2020 10 28.
Article en En | MEDLINE | ID: mdl-32946744
ABSTRACT
Uncovering the neural mechanisms underlying human natural ambulatory behavior is a major challenge for neuroscience. Current commercially available implantable devices that allow for recording and stimulation of deep brain activity in humans can provide invaluable intrinsic brain signals but are not inherently designed for research and thus lack flexible control and integration with wearable sensors. We developed a mobile deep brain recording and stimulation (Mo-DBRS) platform that enables wireless and programmable intracranial electroencephalographic recording and electrical stimulation integrated and synchronized with virtual reality/augmented reality (VR/AR) and wearables capable of external measurements (e.g., motion capture, heart rate, skin conductance, respiration, eye tracking, and scalp EEG). When used in freely moving humans with implanted neural devices, this platform is adaptable to ecologically valid environments conducive to elucidating the neural mechanisms underlying naturalistic behaviors and to the development of viable therapies for neurologic and psychiatric disorders.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Desempeño Psicomotor / Telemetría / Encéfalo / Estimulación Encefálica Profunda / Electroencefalografía / Dispositivos Electrónicos Vestibles Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Desempeño Psicomotor / Telemetría / Encéfalo / Estimulación Encefálica Profunda / Electroencefalografía / Dispositivos Electrónicos Vestibles Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article