Targeting &#945;-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance.

Lemos, Miguel; Venezia, Serena; Refolo, Violetta; Heras-Garvin, Antonio; Schmidhuber, Sabine; Giese, Armin; Leonov, Andrei; Ryazanov, Sergey; Griesinger, Christian; Galabova, Gergana; Staffler, Guenther; Wenning, Gregor Karl; Stefanova, Nadia

Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance.

Lemos, Miguel; Venezia, Serena; Refolo, Violetta; Heras-Garvin, Antonio; Schmidhuber, Sabine; Giese, Armin; Leonov, Andrei; Ryazanov, Sergey; Griesinger, Christian; Galabova, Gergana; Staffler, Guenther; Wenning, Gregor Karl; Stefanova, Nadia.

Afiliación

Lemos M; Division of Neurobiology, Department of Neurology, Innsbruck Medical University, 6020, Innsbruck, Austria.
Venezia S; Division of Neurobiology, Department of Neurology, Innsbruck Medical University, 6020, Innsbruck, Austria.
Refolo V; Division of Neurobiology, Department of Neurology, Innsbruck Medical University, 6020, Innsbruck, Austria.
Heras-Garvin A; Division of Neurobiology, Department of Neurology, Innsbruck Medical University, 6020, Innsbruck, Austria.
Schmidhuber S; AFFIRIS AG, Vienna, Austria.
Giese A; Center for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany.
Leonov A; Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Ryazanov S; Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Griesinger C; Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Galabova G; AFFIRIS AG, Vienna, Austria.
Staffler G; Present Address: Origenis GmbH, Munich, Germany.
Wenning GK; AFFIRIS AG, Vienna, Austria.
Stefanova N; Division of Neurobiology, Department of Neurology, Innsbruck Medical University, 6020, Innsbruck, Austria.

Transl Neurodegener ; 9(1): 38, 2020 09 24.

Article en En | MEDLINE | ID: mdl-32972456

Asunto(s)

Benzodioxoles/administración & dosificación; Sistemas de Liberación de Medicamentos/métodos; Factores Inmunológicos/administración & dosificación; Atrofia de Múltiples Sistemas/tratamiento farmacológico; Atrofia de Múltiples Sistemas/metabolismo; Pirazoles/administración & dosificación; alfa-Sinucleína/metabolismo; Animales; Femenino; Masculino; Ratones; Ratones Transgénicos; Atrofia de Múltiples Sistemas/genética; Atrofia de Múltiples Sistemas/patología; Enfermedades Neurodegenerativas/tratamiento farmacológico; Enfermedades Neurodegenerativas/genética; Enfermedades Neurodegenerativas/metabolismo; Enfermedades Neurodegenerativas/patología; alfa-Sinucleína/genética

Palabras clave

Immunotherapy; Microglia; Oligomer modulation; Substantia nigra; Target engagement; α-Synuclein

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pirazoles / Sistemas de Liberación de Medicamentos / Atrofia de Múltiples Sistemas / Benzodioxoles / Alfa-Sinucleína / Factores Inmunológicos Tipo de estudio: Prognostic_studies Idioma: En Revista: Transl Neurodegener Año: 2020 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google