Antiulcerogenic effect of melittin via mitigating TLR4/TRAF6 mediated NF-&#954;B and p38MAPK pathways in acetic acid-induced ulcerative colitis in mice.

Ahmedy, Omaima A; Ibrahim, Sherehan M; Salem, Heba H; Kandil, Esraa A

Antiulcerogenic effect of melittin via mitigating TLR4/TRAF6 mediated NF-κB and p38MAPK pathways in acetic acid-induced ulcerative colitis in mice.

Ahmedy, Omaima A; Ibrahim, Sherehan M; Salem, Heba H; Kandil, Esraa A.

Afiliación

Ahmedy OA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562, Cairo, Egypt. Electronic address: o_ahmedy@yahoo.ca.
Ibrahim SM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562, Cairo, Egypt.
Salem HH; Department of Biochemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562, Cairo, Egypt; College of Pharmacy, King Khalid University, Abha, 61441, Saudi Arabia.
Kandil EA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562, Cairo, Egypt.

Chem Biol Interact ; 331: 109276, 2020 Nov 01.

Article en En | MEDLINE | ID: mdl-33002459

Asunto(s)

Antiulcerosos/farmacología; Meliteno/farmacología; Transducción de Señal/efectos de los fármacos; Factor 6 Asociado a Receptor de TNF/metabolismo; Receptor Toll-Like 4/metabolismo; Ácido Acético/toxicidad; Administración Oral; Animales; Antiulcerosos/uso terapéutico; Colitis Ulcerosa/inducido químicamente; Colitis Ulcerosa/tratamiento farmacológico; Colitis Ulcerosa/patología; Colon/metabolismo; Colon/patología; Ciclooxigenasa 2/metabolismo; Interleucina-6/metabolismo; Malondialdehído/metabolismo; Meliteno/uso terapéutico; Ratones; FN-kappa B/metabolismo; Estrés Oxidativo/efectos de los fármacos; Superóxido Dismutasa/metabolismo; Factor de Necrosis Tumoral alfa/metabolismo; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo

Palabras clave

Inflammation; Melittin; TLR4; TRAF6; Ulcerative colitis; sPLA2

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Transducción de Señal / Factor 6 Asociado a Receptor de TNF / Receptor Toll-Like 4 / Meliteno / Antiulcerosos Tipo de estudio: Prognostic_studies Idioma: En Revista: Chem Biol Interact Año: 2020 Tipo del documento: Article

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