Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome.

Bertram, Karl; El Ayoubi, Leyla; Dybkov, Olexandr; Agafonov, Dmitry E; Will, Cindy L; Hartmuth, Klaus; Urlaub, Henning; Kastner, Berthold; Stark, Holger; Lührmann, Reinhard

Bertram, Karl; El Ayoubi, Leyla; Dybkov, Olexandr; Agafonov, Dmitry E; Will, Cindy L; Hartmuth, Klaus; Urlaub, Henning; Kastner, Berthold; Stark, Holger; Lührmann, Reinhard.

Afiliación

Bertram K; Department of Structural Dynamics, MPI for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
El Ayoubi L; Cellular Biochemistry, MPI for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Dybkov O; Cellular Biochemistry, MPI for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Agafonov DE; Cellular Biochemistry, MPI for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Will CL; Cellular Biochemistry, MPI for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Hartmuth K; Cellular Biochemistry, MPI for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.
Urlaub H; Bioanalytical Mass Spectrometry, MPI for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany; Bioanalytics Group, Institute for Clinical Chemistry, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany.
Kastner B; Cellular Biochemistry, MPI for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany. Electronic address: b.kastner@mpibpc.mpg.de.
Stark H; Department of Structural Dynamics, MPI for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany. Electronic address: hstark1@gwdg.de.
Lührmann R; Cellular Biochemistry, MPI for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany. Electronic address: reinhard.luehrmann@mpibpc.mpg.de.

Mol Cell ; 80(1): 127-139.e6, 2020 10 01.

Article en En | MEDLINE | ID: mdl-33007253

Asunto(s)

Factores de Empalme de ARN/química; Factores de Empalme de ARN/metabolismo; Empalmosomas/metabolismo; Animales; Catálisis; Células HeLa; Humanos; Intrones/genética; Modelos Moleculares; Complejos Multiproteicos/metabolismo; Complejos Multiproteicos/ultraestructura; Unión Proteica; Estabilidad Proteica; ARN/química; ARN/metabolismo; Ribonucleoproteínas/metabolismo; Saccharomyces cerevisiae/metabolismo; Especificidad de la Especie; Factores de Tiempo

Palabras clave

C complex; cryo-EM; human spliceosome; metazoan-specific splicing factors; pre-mRNA splicing; spliceosome structure; step 1 spliceosome

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Empalmosomas / Factores de Empalme de ARN Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article

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