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Population Size, Sex and Purifying Selection: Comparative Genomics of Two Sister Taxa of the Wild Yeast Saccharomyces paradoxus.
Koufopanou, Vassiliki; Lomas, Susan; Pronina, Olga; Almeida, Pedro; Sampaio, Jose Paulo; Mousseau, Timothy; Liti, Gianni; Burt, Austin.
Afiliación
  • Koufopanou V; Department of Life Sciences, Imperial College London, Ascot, Berks, United Kingdom.
  • Lomas S; Department of Life Sciences, Imperial College London, Ascot, Berks, United Kingdom.
  • Pronina O; Institute of Cell Biology and Genetic Engineering, NAS of Ukraine, Kyiv, Ukraine.
  • Almeida P; Department of Genetics, Evolution & Environment, University College London, United Kingdom.
  • Sampaio JP; UCIBIO, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Portugal.
  • Mousseau T; Department of Biological Sciences, University of South Carolina.
  • Liti G; CNRS, INSERM, IRCAN, Universite Cote d' Azur, Nice, France.
  • Burt A; Department of Life Sciences, Imperial College London, Ascot, Berks, United Kingdom.
Genome Biol Evol ; 12(9): 1636-1645, 2020 09 01.
Article en En | MEDLINE | ID: mdl-33011797
ABSTRACT
This study uses population genomic data to estimate demographic and selection parameters in two sister lineages of the wild yeast Saccharomyces paradoxus and compare their evolution. We first estimate nucleotide and recombinational diversities in each of the two lineages to infer their population size and frequency of sex and then analyze the rate of mutation accumulation since divergence from their inferred common ancestor to estimate the generation time and efficacy of selection. We find that one of the lineages has significantly higher silent nucleotide diversity and lower linkage disequilibrium, indicating a larger population with more frequent sexual generations. The same lineage also shows shorter generation time and higher efficacy of purifying selection, the latter consistent with the finding of larger population size and more frequent sex. Similar analyses are also performed on the ancestries of individual strains within lineages and we find significant differences between strains implying variation in rates of mitotic cell divisions. Our sample includes some strains originating in the Chernobyl nuclear-accident exclusion zone, which has been subjected to high levels of radiation for nearly 30 years now. We find no evidence, however, for increased rates of mutation. Finally, there is a positive correlation between rates of mutation accumulation and length of growing period, as measured by latitude of the place of origin of strains. Our study illustrates the power of genomic analyses in estimating population and life history parameters and testing predictions based on population genetic theory.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Saccharomyces / Selección Genética / Genoma Fúngico / Acumulación de Mutaciones Tipo de estudio: Incidence_studies / Prognostic_studies Idioma: En Revista: Genome Biol Evol Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Saccharomyces / Selección Genética / Genoma Fúngico / Acumulación de Mutaciones Tipo de estudio: Incidence_studies / Prognostic_studies Idioma: En Revista: Genome Biol Evol Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article