SPARC promotes insulin secretion through down-regulation of RGS4 protein in pancreatic ß cells.

Hu, Li; He, Fengli; Huang, Meifeng; Zhao, Qian; Cheng, Lamei; Said, Neveen; Zhou, Zhiguang; Liu, Feng; Dai, Yan-Shan

Hu, Li; He, Fengli; Huang, Meifeng; Zhao, Qian; Cheng, Lamei; Said, Neveen; Zhou, Zhiguang; Liu, Feng; Dai, Yan-Shan.

Afiliación

Hu L; Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
He F; National Clinical Research Center for Metabolic Disease, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Huang M; Metabolic Syndrome Research Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhao Q; Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Cheng L; National Clinical Research Center for Metabolic Disease, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Said N; Metabolic Syndrome Research Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhou Z; Department of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Liu F; National Clinical Research Center for Metabolic Disease, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Dai YS; Metabolic Syndrome Research Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Sci Rep ; 10(1): 17581, 2020 10 16.

Article en En | MEDLINE | ID: mdl-33067534

Asunto(s)

Secreción de Insulina/efectos de los fármacos; Osteonectina/metabolismo; Proteínas RGS/metabolismo; Animales; Diabetes Mellitus Experimental/metabolismo; Glucosa/metabolismo; Intolerancia a la Glucosa/metabolismo; Humanos; Insulina/metabolismo; Células Secretoras de Insulina/metabolismo; Islotes Pancreáticos/metabolismo; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Osteonectina/genética; Oxotremorina/análogos & derivados; Oxotremorina/farmacología; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas RGS/fisiología; Receptor Muscarínico M3/efectos de los fármacos; Receptor Muscarínico M3/metabolismo

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Osteonectina / Proteínas RGS / Secreción de Insulina Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article

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