Overgrowth syndromes and new therapies.
Semin Pediatr Surg
; 29(5): 150974, 2020 Oct.
Article
en En
| MEDLINE
| ID: mdl-33069285
ABSTRACT
Overgrowth syndromes represent a diverse group of disorders with overlapping features. Interdisciplinary management by a team of experts in vascular anomalies is crucial for establishing the correct diagnosis and optimizing outcomes for these patients. Unique management considerations include increased risk for thrombosis and in some cases, cancer. In recent years, research has demonstrated that these disorders are primarily caused by somatic mutations in growth pathways, particularly the PI3K-mTOR pathway. This improved understanding had led to promising new therapies for this group of patients.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Hamartoma Múltiple
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Síndrome de Sturge-Weber
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Síndrome de Proteo
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Síndrome de Klippel-Trenaunay-Weber
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Malformaciones Vasculares
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Lipoma
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Anomalías Musculoesqueléticas
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Nevo
Idioma:
En
Revista:
Semin Pediatr Surg
Asunto de la revista:
PEDIATRIA
Año:
2020
Tipo del documento:
Article