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The structural basis for an on-off switch controlling Gßγ-mediated inhibition of TRPM3 channels.
Behrendt, Marc; Gruss, Fabian; Enzeroth, Raissa; Dembla, Sandeep; Zhao, Siyuan; Crassous, Pierre-Antoine; Mohr, Florian; Nys, Mieke; Louros, Nikolaos; Gallardo, Rodrigo; Zorzini, Valentina; Wagner, Doris; Economou, Anastassios; Rousseau, Frederic; Schymkowitz, Joost; Philipp, Stephan E; Rohacs, Tibor; Ulens, Chris; Oberwinkler, Johannes.
Afiliación
  • Behrendt M; Institut für Physiologie und Pathophysiologie, Philipps-Universität Marburg, 35037 Marburg, Germany.
  • Gruss F; Center for Mind, Brain and Behavior (CMBB), Philipps-Universität Marburg and Justus-Liebig-Universität Giessen, 35032 Marburg, Germany.
  • Enzeroth R; Laboratory of Structural Neurobiology, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
  • Dembla S; Institut für Physiologie und Pathophysiologie, Philipps-Universität Marburg, 35037 Marburg, Germany.
  • Zhao S; Center for Mind, Brain and Behavior (CMBB), Philipps-Universität Marburg and Justus-Liebig-Universität Giessen, 35032 Marburg, Germany.
  • Crassous PA; Institut für Physiologie und Pathophysiologie, Philipps-Universität Marburg, 35037 Marburg, Germany.
  • Mohr F; Center for Mind, Brain and Behavior (CMBB), Philipps-Universität Marburg and Justus-Liebig-Universität Giessen, 35032 Marburg, Germany.
  • Nys M; Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ 07103.
  • Louros N; Department of Pharmacology, Physiology and Neuroscience, Rutgers New Jersey Medical School, Newark, NJ 07103.
  • Gallardo R; Institut für Physiologie und Pathophysiologie, Philipps-Universität Marburg, 35037 Marburg, Germany.
  • Zorzini V; Laboratory of Structural Neurobiology, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
  • Wagner D; Switch Laboratory, VIB Center for Brain and Disease Research, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
  • Economou A; Switch Laboratory, VIB Center for Brain and Disease Research, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
  • Rousseau F; Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.
  • Schymkowitz J; Institut für Physiologie und Pathophysiologie, Philipps-Universität Marburg, 35037 Marburg, Germany.
  • Philipp SE; Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.
  • Rohacs T; Switch Laboratory, VIB Center for Brain and Disease Research, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
  • Ulens C; Switch Laboratory, VIB Center for Brain and Disease Research, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
  • Oberwinkler J; Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, 66421 Homburg, Germany.
Proc Natl Acad Sci U S A ; 117(46): 29090-29100, 2020 11 17.
Article en En | MEDLINE | ID: mdl-33122432

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Subunidades beta de la Proteína de Unión al GTP / Subunidades gamma de la Proteína de Unión al GTP / Canales Catiónicos TRPM Tipo de estudio: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Subunidades beta de la Proteína de Unión al GTP / Subunidades gamma de la Proteína de Unión al GTP / Canales Catiónicos TRPM Tipo de estudio: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article