The role of interleukin-1 family members in hyperuricemia and gout.
Joint Bone Spine
; 88(2): 105092, 2021 Mar.
Article
en En
| MEDLINE
| ID: mdl-33129923
ABSTRACT
BACKGROUND:
Interleukin (IL)-1 family cytokines and their receptors have important roles in innate and partly in adaptive immunity. The family consists of 11 members of which IL-1α, IL-1ß, IL-18, IL-33, IL-36α, IL-36ß and IL-36γ are considered pro-inflammatory and IL-1Ra, IL-36Ra, IL-37 and IL-38 anti-inflammatory. Whereas IL-1ß has a known pivotal role in gout, increasing evidence suggests other IL-1 family members are also involved in the pathogenesis of hyperuricemia and gout flares.FINDINGS:
Studies indicate IL-1α, like IL-1ß, plays an essential role in the pathogenesis of gout flares. IL-18, although elevated in patients with gout, does not contribute to MSU crystal-induced inflammation, but may be involved in the subsequent development of cardiovascular disease in individuals with gout. The role of the pro-inflammatory cytokine IL-36 in gout remains elusive. In contrast, IL-1Ra, IL-33, IL-37 and IL-38 inhibit MSU crystal-induced inflammation and therefore have therapeutic potential for treatment of gout flares. In addition to existing IL-1ß blockers, several new therapeutics to treat gout are being developed either inhibiting the transcription or maturation of IL-1ß.CONCLUSION:
In this review, IL-1 family cytokines are discussed in the context of hyperuricemia and gout. Finally, current and novel therapeutic options for targeting IL-1 are reviewed.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Interleucina-1
/
Hiperuricemia
/
Gota
Idioma:
En
Revista:
Joint Bone Spine
Asunto de la revista:
REUMATOLOGIA
Año:
2021
Tipo del documento:
Article