Changes in bone mineral density after parathyroidectomy in patients with moderate to severe primary hyperparathyroidism.
J Int Med Res
; 48(10): 300060520964698, 2020 Oct.
Article
en En
| MEDLINE
| ID: mdl-33135515
ABSTRACT
OBJECTIVE:
Primary hyperparathyroidism (PHPT) is relatively common in China and results in severe damage to the skeletal system. This study aimed to investigate changes in bone mineral density (BMD) over 2 years in patients with PHPT after parathyroidectomy.METHODS:
This retrospective cohort study included patients with PHPT who underwent parathyroidectomy between January 2010 and December 2015. BMD and T-scores and Z-scores of the lumbar spine (L1, L2, L3, and L4) and total hip (femoral neck, great trochanter, and Ward's triangle) at baseline and 2 years after surgery were measured by dual-energy X-ray absorptiometry.RESULTS:
Thirty patients with moderate to severe PHPT (17 men and 13 women) aged 38.90±15.48 years were included. BMD, and T-score and Z-score values at the lumbar spine and total hip at 6 months, 1 year, and 2 years after parathyroidectomy were significantly improved compared with preoperative values. Improvement in BMD was largest at L4 (46.7%) and smallest at L1 (37.4%) in the lumbar spine 2 years after parathyroidectomy. For the total hip, the increase in BMD was largest at Ward's triangle (42.6%) and smallest at the femoral neck (37.5%).CONCLUSIONS:
BMD of the lumbar spine and total hip is improved after parathyroidectomy in patients with PHPT.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Densidad Ósea
/
Hiperparatiroidismo Primario
Tipo de estudio:
Observational_studies
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Int Med Res
Año:
2020
Tipo del documento:
Article