Countermeasure and therapeutic: A(1-7) to treat acute respiratory distress syndrome due to COVID-19 infection.
J Renin Angiotensin Aldosterone Syst
; 21(4): 1470320320972018, 2020.
Article
en En
| MEDLINE
| ID: mdl-33169644
ABSTRACT
In the wake of the COVID-19 pandemic it has become clear that there is a need for therapies that are capable of reducing damage caused to patients from infections. Infections that induce Acute Respiratory Distress Syndrome (ARDS) are especially devastating because lung damage is so critical and difficult to manage. Angiotensin (1-7) [A(1-7)] has already been shown to protect pulmonary health and architecture in various models of disease. There is also evidence that A(1-7) can modulate immune function and protect various organs (lung, kidney, and heart) from oxidative damage and inflammation. Here we focus on making a case for the development of novel therapies that target the protective arm of the Renin Angiotensin System (RAS).
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Neumonía Viral
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Síndrome de Dificultad Respiratoria
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Angiotensina I
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Infecciones por Coronavirus
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Betacoronavirus
Idioma:
En
Revista:
J Renin Angiotensin Aldosterone Syst
Asunto de la revista:
FISIOLOGIA
Año:
2020
Tipo del documento:
Article