A compound downregulation of SRRM2 and miR-27a-3p with upregulation of miR-27b-3p in PBMCs of Parkinson's patients is associated with the early stage onset of disease.

Fazeli, Soudabeh; Motovali-Bashi, Majid; Peymani, Maryam; Hashemi, Motahare-Sadat; Etemadifar, Masoud; Nasr-Esfahani, Mohammad Hossein; Ghaedi, Kamran

Fazeli, Soudabeh; Motovali-Bashi, Majid; Peymani, Maryam; Hashemi, Motahare-Sadat; Etemadifar, Masoud; Nasr-Esfahani, Mohammad Hossein; Ghaedi, Kamran.

Afiliación

Fazeli S; Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Motovali-Bashi M; Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Peymani M; Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Shahrekord, Iran.
Hashemi MS; Department of Animal Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
Etemadifar M; Department of Animal Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
Nasr-Esfahani MH; Department of Neurology and Isfahan Neurosurgery Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Ghaedi K; Department of Animal Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

PLoS One ; 15(11): e0240855, 2020.

Article en En | MEDLINE | ID: mdl-33171483

Asunto(s)

MicroARNs/genética; Enfermedad de Parkinson/diagnóstico; Enfermedad de Parkinson/genética; Proteínas de Unión al ARN/genética; Anciano; Envejecimiento/genética; Envejecimiento/metabolismo; Estudios de Casos y Controles; Biología Computacional; Simulación por Computador; Progresión de la Enfermedad; Regulación hacia Abajo; Diagnóstico Precoz; Femenino; Marcadores Genéticos; Humanos; Leucocitos Mononucleares/metabolismo; Masculino; MicroARNs/metabolismo; Persona de Mediana Edad; Enfermedad de Parkinson/etiología; Empalme del ARN; Proteínas de Unión al ARN/metabolismo; Regulación hacia Arriba

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Proteínas de Unión al ARN / MicroARNs Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article

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