Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-&#954;B and PI3K/Akt pathways in C57BL/6J mice.

Feng, Zhongwen; Pang, Lijun; Chen, Siyun; Pang, Xiaohong; Huang, Yushen; Qiao, Qian; Wang, Yinglian; Vonglorkham, Sayyaphone; Huang, Quanfang; Lin, Xing; Wei, Jinbin

Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.

Feng, Zhongwen; Pang, Lijun; Chen, Siyun; Pang, Xiaohong; Huang, Yushen; Qiao, Qian; Wang, Yinglian; Vonglorkham, Sayyaphone; Huang, Quanfang; Lin, Xing; Wei, Jinbin.

Afiliación

Feng Z; Guangxi Medical University, Nanning 530021, China.
Pang L; Guangxi Medical University, Nanning 530021, China.
Chen S; Guangxi Medical University, Nanning 530021, China.
Pang X; Guangxi Medical University, Nanning 530021, China.
Huang Y; Guangxi Medical University, Nanning 530021, China.
Qiao Q; Guangxi Medical University, Nanning 530021, China.
Wang Y; Traditional Chinese Medicine Hospital of Yulin, Yulin 537000, China.
Vonglorkham S; Guangxi Medical University, Nanning 530021, China.
Huang Q; The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China. Electronic address: hqf00@126.com.
Lin X; Guangxi Medical University, Nanning 530021, China. Electronic address: gxlx60@163.com.
Wei J; Guangxi Medical University, Nanning 530021, China. Electronic address: wjbguangxi@sina.cn.

Int Immunopharmacol ; 88: 107003, 2020 Nov.

Article en En | MEDLINE | ID: mdl-33182043

Asunto(s)

Flavonoides/uso terapéutico; Glicósidos/uso terapéutico; FN-kappa B/metabolismo; Enfermedad del Hígado Graso no Alcohólico/inducido químicamente; Enfermedad del Hígado Graso no Alcohólico/tratamiento farmacológico; Fosfatidilinositol 3-Quinasas/metabolismo; Receptor Toll-Like 4/metabolismo; Animales; Dexametasona/toxicidad; Regulación de la Expresión Génica/efectos de los fármacos; Peroxidación de Lípido/efectos de los fármacos; Masculino; Ratones; Ratones Endogámicos C57BL; FN-kappa B/genética; Estrés Oxidativo/efectos de los fármacos; Fosfatidilinositol 3-Quinasas/genética; Proteínas Proto-Oncogénicas c-akt/genética; Proteínas Proto-Oncogénicas c-akt/metabolismo; Distribución Aleatoria; Receptor Toll-Like 4/genética

Palabras clave

Didymin; Lipidosis; Non-alcoholic fatty liver disease; PI3K/Akt pathway; TLR4/NF-κB pathway

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Flavonoides / FN-kappa B / Fosfatidilinositol 3-Quinasas / Receptor Toll-Like 4 / Enfermedad del Hígado Graso no Alcohólico / Glicósidos Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2020 Tipo del documento: Article

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