IgE and mast cells: The endogenous adjuvant.
Adv Immunol
; 148: 93-153, 2020.
Article
en En
| MEDLINE
| ID: mdl-33190734
ABSTRACT
Mast cells and IgE are most familiar as the effectors of type I hypersensitivity reactions including anaphylaxis. It is becoming clear however that this pair has important immunomodulatory effects on innate and adaptive cells of the immune system. In this purview, they act as endogenous adjuvants to ignite evolving immune responses, promote the transition of allergic disease into chronic illness and disrupt the development of active mechanisms of tolerance to ingested foods. Suppression of IgE-mediated mast cell activation can be exerted by molecules targeting IgE, FcÉRI or signaling kinases including Syk, or by IgG antibodies acting via inhibitory Fcγ receptors. In 2015 we reviewed the evidence for the adjuvant functions of mast cells. This update includes the original text, incorporates some important developments in the field over the past five years and discusses how interventions targeting these pathways might have promise in the development of strategies to treat allergic disease.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Inmunoglobulina E
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Desensibilización Inmunológica
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Receptores de IgG
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Linfocitos T Reguladores
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Células Th2
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Hipersensibilidad a los Alimentos
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Mastocitos
Idioma:
En
Revista:
Adv Immunol
Año:
2020
Tipo del documento:
Article