BODIPY based red emitters: Synthesis, computational and biological studies.
Bioorg Chem
; 106: 104467, 2021 01.
Article
en En
| MEDLINE
| ID: mdl-33223201
ABSTRACT
Donor-Acceptor type BODIPYs with strong absorption and fluorescence in the red region (550-800 nm) are reported. The aromatic groups like N-butylcarbazole/ N-butylphenothiazine/ benzothiadiazole were attached to the C-8 position of the BODIPY core with furan or thiophene spacers. TD-DFT studies indicated significant charge distribution between C-8 aromatic heterocycles and BODIPY core in all the molecules. The in-vitro studies of the N-butylcarbazole substituted BODIPYs indicated significant localization in the endoplasmic reticulum and lysosomes of the cancer cells. The BODIPYs showed decent cytotoxicity after 48 h incubation period (14.9 to 31.8 µM) in HeLa and A549 cancer cells, indicating their potential application as theranostic agents.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Compuestos de Boro
/
Colorantes Fluorescentes
/
Compuestos Heterocíclicos
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Bioorg Chem
Año:
2021
Tipo del documento:
Article