A forced swim-based rat model of premenstrual depression: effects of hormonal changes and drug intervention.
Aging (Albany NY)
; 12(23): 24357-24370, 2020 11 21.
Article
en En
| MEDLINE
| ID: mdl-33229622
ABSTRACT
Premenstrual dysphoric disorder (PMDD), a form of premenstrual syndrome (PMS), is a severe health disturbance that affects a patient's emotions; it is caused by periodic psychological symptoms, and its pathogenesis remains unclear. As depression-like symptoms are found in a majority of clinical cases, a reliable animal model of premenstrual depression is indispensable to understand the pathogenesis. Herein, we describe a novel rat model of premenstrual depression, based on the forced swimming test, with a regular estrous cycle. The results showed that in the estrous cycle, the depression-like behavior of rats occurred in the non-receptive phase and disappeared in the receptive phase. Following ovariectomy, the depression-like symptoms disappeared and returned after a hormone priming regimen. Moreover, fluoxetine, an anti-depressant, could reverse the behavioral symptoms in these model rats with normal estrous cycle. Further, the model rats showed significant changes in the serum levels of estrogen and progesterone, hippocampal levels of allopregnanolone, 5-hydroxytryptamine, norepinephrine, and γ-aminobutyric acid (GABA), and in the expression of GABAA receptor 4α subunit, all of which were reversed to physiological levels by fluoxetine. Overall, we established a reliable and standardized rat model of premenstrual depression, which may facilitate the elucidation of PMS/PMDD pathogenesis and development of related therapies.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Progesterona
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Conducta Animal
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Terapia de Reemplazo de Estrógeno
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Fluoxetina
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Antidepresivos de Segunda Generación
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Ciclo Estral
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Estradiol
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Trastorno Disfórico Premenstrual
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Hipocampo
Idioma:
En
Revista:
Aging (Albany NY)
Asunto de la revista:
GERIATRIA
Año:
2020
Tipo del documento:
Article