Combined adipose mesenchymal stromal cell advanced therapy resolved a recalcitrant leg ulcer in an 85-year-old patient.
Regen Med
; 15(9): 2053-2065, 2020 09.
Article
en En
| MEDLINE
| ID: mdl-33245008
ABSTRACT
Venous leg ulcers (VLU) represent an uphill economic, health and social burden, aggravated in the elderly. Best-practice care interventions are often insufficient and alternative therapies need to be explored. Herein, we have treated for the first time a chronic VLU in an elderly patient by combining cell therapy and tissue engineering in the context of a compassionate use. The administration of allogeneic adipose-derived mesenchymal stromal cells (MSCs) embedded in a plasma-based bioengineered dermis covering the ulcer bed and also injected into the ulcer margins led to the complete closure of a 10-year recalcitrant VLU in an 85-year-old patient. Regenerative properties of MSCs might be boosted by the use of bioengineered matrices for their delivery.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Úlcera Varicosa
/
Células Madre Mesenquimatosas
/
Úlcera de la Pierna
Tipo de estudio:
Guideline
Idioma:
En
Revista:
Regen Med
Año:
2020
Tipo del documento:
Article