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Towards a unified open access dataset of molecular interactions.
Porras, Pablo; Barrera, Elisabet; Bridge, Alan; Del-Toro, Noemi; Cesareni, Gianni; Duesbury, Margaret; Hermjakob, Henning; Iannuccelli, Marta; Jurisica, Igor; Kotlyar, Max; Licata, Luana; Lovering, Ruth C; Lynn, David J; Meldal, Birgit; Nanduri, Bindu; Paneerselvam, Kalpana; Panni, Simona; Pastrello, Chiara; Pellegrini, Matteo; Perfetto, Livia; Rahimzadeh, Negin; Ratan, Prashansa; Ricard-Blum, Sylvie; Salwinski, Lukasz; Shirodkar, Gautam; Shrivastava, Anjalia; Orchard, Sandra.
Afiliación
  • Porras P; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton, Cambridge, CB10 1SD, UK.
  • Barrera E; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton, Cambridge, CB10 1SD, UK.
  • Bridge A; SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, 1 rue Michel Servet, CH-1211, Geneva, Switzerland.
  • Del-Toro N; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton, Cambridge, CB10 1SD, UK.
  • Cesareni G; University of Rome Tor Vergata, Rome, Italy.
  • Duesbury M; IRCCS Fondazione Santa Lucia, 00143, Rome, Italy.
  • Hermjakob H; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton, Cambridge, CB10 1SD, UK.
  • Iannuccelli M; UCLA-DOE Institute, University of California, Los Angeles, CA, 90095, USA.
  • Jurisica I; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton, Cambridge, CB10 1SD, UK.
  • Kotlyar M; University of Rome Tor Vergata, Rome, Italy.
  • Licata L; Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD-407, Toronto, ON, M5T 0S8, Canada.
  • Lovering RC; Departments of Medical Biophysics, and Computer Science, University of Toronto, Toronto, ON, Canada.
  • Lynn DJ; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.
  • Meldal B; Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD-407, Toronto, ON, M5T 0S8, Canada.
  • Nanduri B; University of Rome Tor Vergata, Rome, Italy.
  • Paneerselvam K; Functional Gene Annotation, Preclinical and Fundamental Science, UCL Institute of Cardiovascular Science, University College London, London, WC1E 6JF, UK.
  • Panni S; Computational and Systems Biology Program, Precision Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.
  • Pastrello C; College of Medicine and Public Health, Flinders University, Bedford Park, SA, 5042, Australia.
  • Pellegrini M; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton, Cambridge, CB10 1SD, UK.
  • Perfetto L; Institute for Genomics, Biocomputing and Biotechnology, Mississippi State University, Starkville, MS, USA.
  • Rahimzadeh N; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton, Cambridge, CB10 1SD, UK.
  • Ratan P; Università della Calabria, Dipartimento di Biologia, Ecologia e Scienze della Terra, Via Pietro Bucci Cubo 6/C, Rende, CS, Italy.
  • Ricard-Blum S; Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network, 60 Leonard Avenue, 5KD-407, Toronto, ON, M5T 0S8, Canada.
  • Salwinski L; Department of Molecular, Cell and Developmental Biology, UCLA, Box 951606, Los Angeles, CA, 90095-1606, USA.
  • Shirodkar G; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Campus, Hinxton, Cambridge, CB10 1SD, UK.
  • Shrivastava A; UCLA-DOE Institute, University of California, Los Angeles, CA, 90095, USA.
  • Orchard S; UCLA-DOE Institute, University of California, Los Angeles, CA, 90095, USA.
Nat Commun ; 11(1): 6144, 2020 12 01.
Article en En | MEDLINE | ID: mdl-33262342
ABSTRACT
The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Acceso a la Información / Bases de Datos Genéticas Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Acceso a la Información / Bases de Datos Genéticas Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2020 Tipo del documento: Article