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Pimavanserin, a 5HT2A receptor inverse agonist, rapidly suppresses Aß production and related pathology in a mouse model of Alzheimer's disease.
Yuede, Carla M; Wallace, Clare E; Davis, Todd A; Gardiner, Woodrow D; Hettinger, Jane C; Edwards, Hannah M; Hendrix, Rachel D; Doherty, Brookelyn M; Yuede, Kayla M; Burstein, Ethan S; Cirrito, John R.
Afiliación
  • Yuede CM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  • Wallace CE; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
  • Davis TA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
  • Gardiner WD; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  • Hettinger JC; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
  • Edwards HM; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
  • Hendrix RD; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  • Doherty BM; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
  • Yuede KM; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
  • Burstein ES; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  • Cirrito JR; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
J Neurochem ; 156(5): 658-673, 2021 03.
Article en En | MEDLINE | ID: mdl-33278025
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piperidinas / Urea / Péptidos beta-Amiloides / Receptor de Serotonina 5-HT2A / Agonismo Inverso de Drogas / Agonistas del Receptor de Serotonina 5-HT2 / Enfermedad de Alzheimer Idioma: En Revista: J Neurochem Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piperidinas / Urea / Péptidos beta-Amiloides / Receptor de Serotonina 5-HT2A / Agonismo Inverso de Drogas / Agonistas del Receptor de Serotonina 5-HT2 / Enfermedad de Alzheimer Idioma: En Revista: J Neurochem Año: 2021 Tipo del documento: Article