Grafts Derived from an &#945;-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson's Disease.

Shrigley, Shelby; Nilsson, Fredrik; Mattsson, Bengt; Fiorenzano, Alessandro; Mudannayake, Janitha; Bruzelius, Andreas; Ottosson, Daniella Rylander; Björklund, Anders; Hoban, Deirdre B; Parmar, Malin

Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson's Disease.

Shrigley, Shelby; Nilsson, Fredrik; Mattsson, Bengt; Fiorenzano, Alessandro; Mudannayake, Janitha; Bruzelius, Andreas; Ottosson, Daniella Rylander; Björklund, Anders; Hoban, Deirdre B; Parmar, Malin.

Afiliación

Shrigley S; Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Nilsson F; Lund Stem Cell Center, Lund University, Lund, Sweden.
Mattsson B; Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Fiorenzano A; Lund Stem Cell Center, Lund University, Lund, Sweden.
Mudannayake J; Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Bruzelius A; Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Ottosson DR; Lund Stem Cell Center, Lund University, Lund, Sweden.
Björklund A; Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.
Hoban DB; Lund Stem Cell Center, Lund University, Lund, Sweden.
Parmar M; Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.

J Parkinsons Dis ; 11(2): 515-528, 2021.

Article en En | MEDLINE | ID: mdl-33361611

Asunto(s)

Células Madre Pluripotentes Inducidas; Oxidopamina/farmacología; Enfermedad de Parkinson; Sinucleinopatías; alfa-Sinucleína/química; Animales; Neuronas Dopaminérgicas/metabolismo; Humanos; Oxidopamina/química; Enfermedad de Parkinson/terapia; Ratas; alfa-Sinucleína/genética

Palabras clave

Parkinson's disease; alpha-synuclein; cell transplantation; dopaminergic neurons

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Oxidopamina / Alfa-Sinucleína / Células Madre Pluripotentes Inducidas / Sinucleinopatías Tipo de estudio: Guideline / Risk_factors_studies Idioma: En Revista: J Parkinsons Dis Año: 2021 Tipo del documento: Article

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