Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?

Palit, Partha; Chattopadhyay, Debprasad; Thomas, Sabu; Kundu, Amit; Kim, Hyung Sik; Rezaei, Nima

Palit, Partha; Chattopadhyay, Debprasad; Thomas, Sabu; Kundu, Amit; Kim, Hyung Sik; Rezaei, Nima.

Afiliación

Palit P; Department of Pharmaceutical Sciences, Drug Discovery Research Laboratory, Assam University, Silchar, Assam-788011 India. Electronic address: itspartha_p@yahoo.com.
Chattopadhyay D; ICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi, 590010, India; ICMR-National Institute of Cholera and Enteric Diseases, Kolkata 700010, India. Electronic address: debprasadc@gmail.com.
Thomas S; School of Chemical Sciences, Mahatma Gandhi University, Kerala 686 560, India. Electronic address: sabuthomas@mgu.ac.in.
Kundu A; School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon 440-746, Republic of Korea.
Kim HS; School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon 440-746, Republic of Korea. Electronic address: hkims@skku.edu.
Rezaei N; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, 14194, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Uni

Phytomedicine ; 85: 153396, 2021 May.

Article en En | MEDLINE | ID: mdl-33380375

Asunto(s)

Tratamiento Farmacológico de COVID-19; Furina/antagonistas & inhibidores; Fitoquímicos/farmacología; Receptores Virales/antagonistas & inhibidores; Serina Endopeptidasas/metabolismo; Inhibidores de Serina Proteinasa/farmacología; Enzima Convertidora de Angiotensina 2/antagonistas & inhibidores; Animales; Furina/metabolismo; Humanos; Ratones; Ratones Noqueados; SARS-CoV-2; Glicoproteína de la Espiga del Coronavirus/metabolismo

Palabras clave

Covid-19; FURIN; Host cell entry inhibitor; Nasal or oral inhaler; TMPRSS2; Virus-host cell interaction blocking

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Receptores Virales / Serina Endopeptidasas / Inhibidores de Serina Proteinasa / Furina / Fitoquímicos / Tratamiento Farmacológico de COVID-19 Idioma: En Revista: Phytomedicine Asunto de la revista: TERAPIAS COMPLEMENTARES Año: 2021 Tipo del documento: Article

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