Investigating the Mechanism of Trimethoprim-Induced Skin Rash and Liver Injury.

Cao, Yanshan; Bairam, Ahsan; Jee, Alison; Liu, Ming; Uetrecht, Jack

Cao, Yanshan; Bairam, Ahsan; Jee, Alison; Liu, Ming; Uetrecht, Jack.

Afiliación

Cao Y; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto M5S3M2, Canada.
Bairam A; Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, Ohio 43614.
Jee A; Department of Pharmacology, University of Toronto, Toronto M5S3M2, Canada.
Liu M; Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, Ohio 43614.
Uetrecht J; Leslie Dan Faculty of Pharmacy, Faculty of Medicine, University of Toronto, Toronto M5S3M2, Canada.

Toxicol Sci ; 180(1): 17-25, 2021 02 26.

Article en En | MEDLINE | ID: mdl-33394045

Asunto(s)

Exantema; Trimetoprim; Animales; Exantema/inducido químicamente; Humanos; Hígado; Ratones; Nevirapina; Ratas; Piel; Trimetoprim/toxicidad

Palabras clave

covalent binding; idiosyncratic drug reaction; reactive metabolite; skin rash; sulfotransferase

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Trimetoprim / Exantema Tipo de estudio: Prognostic_studies Idioma: En Revista: Toxicol Sci Asunto de la revista: TOXICOLOGIA Año: 2021 Tipo del documento: Article

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