Flortaucipir (tau) PET in LGI1 antibody encephalitis.
Ann Clin Transl Neurol
; 8(2): 491-497, 2021 02.
Article
en En
| MEDLINE
| ID: mdl-33410601
ABSTRACT
The contributors to persistent cognitive impairment and hippocampal atrophy in leucine-rich glioma-inactivated 1 antibody encephalitis (LGI1) patients are unknown. We evaluated whether tau neuropathology measured with [18 F]flortaucipir PET neuroimaging associated with persistent cognitive impairment and hippocampal atrophy in four recovering LGI1 patients (3 men; median age, 67 [37-88] years). Imaging findings in cases were compared with those observed in age- and gender-similar cognitively normal individuals (n = 124) and individuals with early-symptomatic Alzheimer disease (n = 11). Elevated [18 F]flortaucipir retention was observed in the two LGI1 patients with hippocampal atrophy and persistent cognitive impairment, including one with autopsy-confirmed Alzheimer disease. Tau neuropathology may associate with cognitive complaints and hippocampal atrophy in recovering LGI1 patients.
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Base de datos:
MEDLINE
Asunto principal:
Encéfalo
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Carbolinas
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Proteínas tau
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Péptidos y Proteínas de Señalización Intracelular
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Tomografía de Emisión de Positrones
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Encefalitis
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Neuroimagen
Idioma:
En
Revista:
Ann Clin Transl Neurol
Año:
2021
Tipo del documento:
Article