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Exome of Radiation-induced Rat Mammary Carcinoma Shows Copy-number Losses and Mutations in Human-relevant Cancer Genes.
Moriyama, Hitomi; Daino, Kazuhiro; Ishikawa, Atsuko; Imaoka, Tatsuhiko; Nishimura, Mayumi; Nishimura, Yukiko; Takabatake, Masaru; Morioka, Takamitsu; Inoue, Kazumasa; Fukushi, Masahiro; Shimada, Yoshiya; Kakinuma, Shizuko.
Afiliación
  • Moriyama H; Department of Radiation Effects Research, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan.
  • Daino K; Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan.
  • Ishikawa A; Present address: Konica Minolta, Inc., Tokyo, Japan.
  • Imaoka T; Department of Radiation Effects Research, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan; daino.kazuhiro@qst.go.jp kakinuma.shizuko@qst.go.jp.
  • Nishimura M; Department of Radiation Effects Research, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan.
  • Nishimura Y; Department of Radiation Effects Research, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan.
  • Takabatake M; Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan.
  • Morioka T; Department of Radiation Effects Research, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan.
  • Inoue K; Department of Radiation Effects Research, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan.
  • Fukushi M; Present address: Institute for Environmental Sciences, Aomori, Japan.
  • Shimada Y; Department of Radiation Effects Research, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan.
  • Kakinuma S; Department of Radiological Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan.
Anticancer Res ; 41(1): 55-70, 2021 01.
Article en En | MEDLINE | ID: mdl-33419799
ABSTRACT
BACKGROUND/

AIM:

Our understanding of cancer risk from neutron exposure is limited. We aimed to reveal the characteristics of mammary carcinomas induced by neutrons. MATERIALS AND

METHODS:

Mammary carcinomas obtained from female Sprague-Dawley rats irradiated at 7 weeks of age with 0.97 Gy neutrons or 4 Gy γ-rays and from non-irradiated rats were classified into luminal and non-luminal subtypes by immunohistochemistry. Their mutational landscapes were determined by whole-exome sequencing.

RESULTS:

Neutrons significantly raised the incidence of luminal mammary carcinomas over the non-luminal subtype. Somatic mutations were identified in cancer genes involved in several signalling pathways, including Keap1/Nrf2, Pi3k/Akt and Wnt/ß-catenin. Focal copy-number losses involving cancer genes were observed mainly in carcinomas from the irradiated rats.

CONCLUSION:

Neutrons increase the incidence of luminal mammary carcinomas, probably through gene mutations similar to those found in human breast cancers, and focal copy-number losses including cancer genes that are characteristics of radiation-induced mammary carcinomas.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Radiación Ionizante / Variaciones en el Número de Copia de ADN / Exoma / Neoplasias Mamarias Experimentales / Mutación Tipo de estudio: Prognostic_studies Idioma: En Revista: Anticancer Res Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Radiación Ionizante / Variaciones en el Número de Copia de ADN / Exoma / Neoplasias Mamarias Experimentales / Mutación Tipo de estudio: Prognostic_studies Idioma: En Revista: Anticancer Res Año: 2021 Tipo del documento: Article