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Probing the substitution pattern of indole-based scaffold reveals potent and selective sphingosine kinase 2 inhibitors.
Congdon, Molly; Fritzemeier, Russell G; Kharel, Yugesh; Brown, Anne M; Serbulea, Vlad; Bevan, David R; Lynch, Kevin R; Santos, Webster L.
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  • Congdon M; Department of Chemistry, Virginia Tech, Blacksburg, VA, 24061, United States; Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA, 24061, United States.
  • Fritzemeier RG; Department of Chemistry, Virginia Tech, Blacksburg, VA, 24061, United States; Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA, 24061, United States.
  • Kharel Y; Department of Pharmacology, University of Virginia, Charlottesville, VA, 22908, United States.
  • Brown AM; Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA, 24061, United States; Department of Biochemistry, Virginia Tech, Blacksburg, VA, 24061, United States; Research and Informatics, University Libraries, Virginia Tech, Blacksburg, VA, 24061, United States.
  • Serbulea V; Department of Pharmacology, University of Virginia, Charlottesville, VA, 22908, United States.
  • Bevan DR; Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA, 24061, United States; Department of Biochemistry, Virginia Tech, Blacksburg, VA, 24061, United States.
  • Lynch KR; Department of Pharmacology, University of Virginia, Charlottesville, VA, 22908, United States.
  • Santos WL; Department of Chemistry, Virginia Tech, Blacksburg, VA, 24061, United States; Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA, 24061, United States. Electronic address: santosw@vt.edu.
Eur J Med Chem ; 212: 113121, 2021 Feb 15.
Article en En | MEDLINE | ID: mdl-33445156
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fosfotransferasas (Aceptor de Grupo Alcohol) / Inhibidores Enzimáticos / Indoles Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fosfotransferasas (Aceptor de Grupo Alcohol) / Inhibidores Enzimáticos / Indoles Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article