Interaction of nobiletin with methotrexate ameliorates 7-OH methotrexate-induced nephrotoxicity through endoplasmic reticulum stress-dependent PERK/CHOP signaling pathway.

Song, Yurong; Liu, Linlin; Liu, Bin; Liu, Rui; Chen, Youwen; Li, Chenxi; Liu, Guangzhi; Song, Zhiqian; Lu, Cheng; Lu, Aiping; Liu, Yuanyan

Song, Yurong; Liu, Linlin; Liu, Bin; Liu, Rui; Chen, Youwen; Li, Chenxi; Liu, Guangzhi; Song, Zhiqian; Lu, Cheng; Lu, Aiping; Liu, Yuanyan.

Afiliación

Song Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Liu L; Dezhou Lianhe Hospital, Dezhou, 253000, China.
Liu B; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Liu R; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China.
Chen Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China.
Li C; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China.
Liu G; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China.
Song Z; Institution of Basic Theory, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Lu C; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China. Electronic address: lv_cheng0816@163.com.
Lu A; School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hongkong, China. Electronic address: lap64067611@126.com.
Liu Y; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100029, China. Electronic address: yyliu_1980@163.com.

Pharmacol Res ; 165: 105371, 2021 03.

Article en En | MEDLINE | ID: mdl-33460792

Asunto(s)

Lesión Renal Aguda/inducido químicamente; Estrés del Retículo Endoplásmico/efectos de los fármacos; Metotrexato/análogos & derivados; Metotrexato/toxicidad; Transducción de Señal/efectos de los fármacos; Factor de Transcripción CHOP/metabolismo; eIF-2 Quinasa/metabolismo; Lesión Renal Aguda/patología; Animales; Calcio/metabolismo; Interacciones Farmacológicas; Flavonas; Citometría de Flujo; Técnica del Anticuerpo Fluorescente; Masculino; Metotrexato/antagonistas & inhibidores; Ratas; Ratas Sprague-Dawley; Especies Reactivas de Oxígeno/metabolismo

Palabras clave

7−OH MTX; 7−OH Methotrexate (PubChem CID: 5484402); Acute kidney injury; Endoplasmic reticulum stress; Methotrexate (PubChem CID: 126941); Nobiletin; Nobiletin (PubChem CID: 72344); PERK/CHOP signaling pathway

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Transducción de Señal / Metotrexato / EIF-2 Quinasa / Factor de Transcripción CHOP / Lesión Renal Aguda / Estrés del Retículo Endoplásmico Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2021 Tipo del documento: Article

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