Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1&#945; regulator.

Isomura, Hisanori; Taguchi, Ayumu; Kajino, Taisuke; Asai, Naoya; Nakatochi, Masahiro; Kato, Seiichi; Suzuki, Keiko; Yanagisawa, Kiyoshi; Suzuki, Motoshi; Fujishita, Teruaki; Yamaguchi, Tomoya; Takahashi, Masahide; Takahashi, Takashi

Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator.

Isomura, Hisanori; Taguchi, Ayumu; Kajino, Taisuke; Asai, Naoya; Nakatochi, Masahiro; Kato, Seiichi; Suzuki, Keiko; Yanagisawa, Kiyoshi; Suzuki, Motoshi; Fujishita, Teruaki; Yamaguchi, Tomoya; Takahashi, Masahide; Takahashi, Takashi.

Afiliación

Isomura H; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Taguchi A; Division of Molecular Diagnostics, Aichi Cancer Center Research Institute, Nagoya, Japan.
Kajino T; Division of Molecular Diagnostics, Aichi Cancer Center Research Institute, Nagoya, Japan.
Asai N; Division of Advanced Cancer Diagnostics, Department of Cancer Diagnostics and Therapeutics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nakatochi M; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kato S; Division of Molecular Diagnostics, Aichi Cancer Center Research Institute, Nagoya, Japan.
Suzuki K; Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yanagisawa K; Department of Pathology, Fujita Health University School of Medicine, Toyoake, Japan.
Suzuki M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Fujishita T; Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.
Yamaguchi T; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takahashi M; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Takahashi T; Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Cancer Sci ; 112(4): 1614-1623, 2021 Apr.

Article en En | MEDLINE | ID: mdl-33506575

Asunto(s)

Adenocarcinoma del Pulmón/genética; Subunidad alfa del Factor 1 Inducible por Hipoxia/genética; Neoplasias Pulmonares/genética; Receptores Huérfanos Similares al Receptor Tirosina Quinasa/genética; Adenocarcinoma del Pulmón/patología; Animales; Línea Celular Tumoral; Regulación hacia Abajo/genética; Regulación Neoplásica de la Expresión Génica/genética; Humanos; Hipoxia/genética; Neoplasias Pulmonares/patología; Ratones; Ratones Endogámicos BALB C; Ratones Endogámicos C57BL; Ratones Noqueados; Ratones Transgénicos; Oncogenes/genética; Transducción de Señal/genética; Factor Nuclear Tiroideo 1/genética; Microambiente Tumoral/genética

Palabras clave

EGFR; HIF-1α; ROR1; genetically engineered mouse model; lung adenocarcinoma

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Subunidad alfa del Factor 1 Inducible por Hipoxia / Receptores Huérfanos Similares al Receptor Tirosina Quinasa / Adenocarcinoma del Pulmón / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Idioma: En Revista: Cancer Sci Año: 2021 Tipo del documento: Article

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