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Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics*.
Sutherland, Mathew; Li, Alice; Kaghad, Anissa; Panagopoulos, Dimitrios; Li, Fengling; Szewczyk, Magdalena; Smil, David; Scholten, Cora; Bouché, Léa; Stellfeld, Timo; Arrowsmith, Cheryl H; Barsyte, Dalia; Vedadi, Masoud; Hartung, Ingo V; Steuber, Holger; Britton, Robert; Santhakumar, Vijayaratnam.
Afiliación
  • Sutherland M; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
  • Li A; Structural Genomics Consortium, University of Toronto, MaRS Centre, South Tower, Suite 700, 101 College Street, Toronto, ON M5G 1L7, Canada.
  • Kaghad A; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
  • Panagopoulos D; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
  • Li F; Structural Genomics Consortium, University of Toronto, MaRS Centre, South Tower, Suite 700, 101 College Street, Toronto, ON M5G 1L7, Canada.
  • Szewczyk M; Structural Genomics Consortium, University of Toronto, MaRS Centre, South Tower, Suite 700, 101 College Street, Toronto, ON M5G 1L7, Canada.
  • Smil D; Structural Genomics Consortium, University of Toronto, MaRS Centre, South Tower, Suite 700, 101 College Street, Toronto, ON M5G 1L7, Canada.
  • Scholten C; Ontario Institute for Cancer Research, 661 University Ave, Toronto, ON M5G 0A3, Canada.
  • Bouché L; Bayer A.G. Research and Development, Pharmaceuticals Muellerstr. 178, 13442, Berlin, Germany.
  • Stellfeld T; Bayer A.G. Research and Development, Pharmaceuticals Muellerstr. 178, 13442, Berlin, Germany.
  • Arrowsmith CH; Bayer A.G. Research and Development, Pharmaceuticals Muellerstr. 178, 13442, Berlin, Germany.
  • Barsyte D; Innovation Campus Berlin, Nuvisan ICB GmbH, Müllerstraße 178, 13353, Berlin, Germany.
  • Vedadi M; Structural Genomics Consortium, University of Toronto, MaRS Centre, South Tower, Suite 700, 101 College Street, Toronto, ON M5G 1L7, Canada.
  • Hartung IV; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, 610 University Ave, Toronto, ON M5G 2C1, Canada.
  • Steuber H; Structural Genomics Consortium, University of Toronto, MaRS Centre, South Tower, Suite 700, 101 College Street, Toronto, ON M5G 1L7, Canada.
  • Britton R; Structural Genomics Consortium, University of Toronto, MaRS Centre, South Tower, Suite 700, 101 College Street, Toronto, ON M5G 1L7, Canada.
  • Santhakumar V; Department of Pharmacology and Toxicology, University of Toronto, 1 King's College Cir, Toronto, ON M5S 1A8, Canada.
ChemMedChem ; 16(7): 1116-1125, 2021 04 08.
Article en En | MEDLINE | ID: mdl-33513288
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / Diseño de Fármacos / Alanina / Inhibidores Enzimáticos / Indoles / Neoplasias / Antineoplásicos Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteína-Arginina N-Metiltransferasas / Diseño de Fármacos / Alanina / Inhibidores Enzimáticos / Indoles / Neoplasias / Antineoplásicos Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2021 Tipo del documento: Article