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Prognostic value of platelet distribution width and mean platelet volume in patients with laryngeal cancer.
Guo, Erliang; Zhang, Cong; Guo, Lunhua; Song, Kaibin; Wang, Guohui; Duan, Chunbin; Yang, Xianguang; Yuan, Zhennan; Guo, Junnan; Sun, Ji; Meng, Hongxue; Chang, Rui; Li, Xiaomei; Xiu, Cheng; An, Changming; Mao, Xionghui; Miao, Susheng.
Afiliación
  • Guo E; Department of Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
  • Zhang C; Department of Head & Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • Guo L; Department of Head & Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • Song K; Department of Head & Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • Wang G; Department of Head & Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • Duan C; Department of Head & Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • Yang X; Department of Head & Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • Yuan Z; Department of Head & Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • Guo J; Department of Head & Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • Sun J; Department of Head & Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • Meng H; Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • Chang R; Department of Head & Neck Surgery, Anyang Cancer Hospital, Anyang, 455000, China.
  • Li X; Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • Xiu C; Department of Head & Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • An C; Department of Head & Neck Surgery, Chinese National Cancer Center & Chinese Academy of Medical Sciences Cancer Hospital, Beijing, 100000, China.
  • Mao X; Department of Head & Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
  • Miao S; Department of Head & Neck Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
Future Oncol ; 17(9): 1025-1037, 2021 Mar.
Article en En | MEDLINE | ID: mdl-33543648
ABSTRACT

Aims:

To investigate the prognostic relevance of platelet volume indices for survival in laryngeal cancer. Patients &

methods:

The study included 640 patients with laryngeal cancer. We analyzed the optimal cutoff values through receiver operating characteristic analysis, then analyzed the univariate factor and multivariate variables. Kaplan-Meier curves and log-rank tests were conducted to compare the overall survival (OS) and recurrence-free survival rates between the groups.

Results:

In multivariate analysis, elevated platelet distribution width (PDW) and PDW/platelet count ratio were significantly correlated with poor prognosis for OS; however, elevated mean platelet volume (MPV) and MPV/platelet count ratio suggested a notable correlation with favorable prognosis for OS. Meanwhile, elevated PDW and decreased MPV were significantly correlated with poor prognosis for recurrence-free survival.

Conclusions:

Our findings indicate that elevated PDW and decreased MPV could serve as independent biomarkers for worse survival in laryngeal cancer.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Plaquetas / Neoplasias Laríngeas Tipo de estudio: Prognostic_studies Idioma: En Revista: Future Oncol Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Plaquetas / Neoplasias Laríngeas Tipo de estudio: Prognostic_studies Idioma: En Revista: Future Oncol Año: 2021 Tipo del documento: Article