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Genomics-driven discovery of a new cyclodepsipeptide from the guanophilic fungus Amphichorda guana.
Liang, Min; Lyu, Hai-Ning; Ma, Zi-Ying; Li, Er-Wei; Cai, Lei; Yin, Wen-Bing.
Afiliación
  • Liang M; State Key Laboratory of Mycology and CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China. cail@im.ac.cn yinwb@im.ac.cn and University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Lyu HN; State Key Laboratory of Mycology and CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China. cail@im.ac.cn yinwb@im.ac.cn and Artemisinin Research Center, and Institute of Chinese Materia Medica, Chi
  • Ma ZY; State Key Laboratory of Mycology and CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China. cail@im.ac.cn yinwb@im.ac.cn and University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Li EW; State Key Laboratory of Mycology and CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China. cail@im.ac.cn yinwb@im.ac.cn.
  • Cai L; State Key Laboratory of Mycology and CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China. cail@im.ac.cn yinwb@im.ac.cn.
  • Yin WB; State Key Laboratory of Mycology and CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P.R. China. cail@im.ac.cn yinwb@im.ac.cn and University of Chinese Academy of Sciences, Beijing, 100049, China.
Org Biomol Chem ; 19(9): 1960-1964, 2021 03 11.
Article en En | MEDLINE | ID: mdl-33599675
ABSTRACT
Two potential non-ribosomal peptide synthetases (NRPSs) were identified in the genome of a guanophilic fungus Amphichorda guana by bioinformatics analysis and gene knockout experiments. Liquid chromatography coupled with mass spectrometry (LC-MS) guided isolation led to the discovery of a new cyclodepsipeptide isaridin H (1) and seven known analogs, desmethylisaridin E (2), isaridin E (3), isariin A (4), iso-isariin B (5), iso-isariin D (6), isariin E (7), and nodupetide (8). The absolute configuration of isaridin H (1) was achieved by Marfey's method. Isaridin H (1) showed significant antifungal activity against Botrytis cinerea and Alternaria solani.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Depsipéptidos / Hypocreales Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Depsipéptidos / Hypocreales Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article