HDAC inhibition prevents transgene expression downregulation and loss-of-function in T-cell-receptor-transduced T cells.

Moore, Tamson V; Scurti, Gina M; DeJong, Matthew; Wang, Siao-Yi; Dalheim, Annika V; Wagner, Courtney R; Hutchens, Kelli A; Speiser, Jodi J; Godellas, Constantine V; Fountain, Chris; Fleser, Jessica; Moudgil, Tarsem; Thomas, Mallory; Murray, David; Curti, Brendan D; Clark, Joseph I; Fox, Bernard A; Nishimura, Michael I

HDAC inhibition prevents transgene expression downregulation and loss-of-function in T-cell-receptor-transduced T cells.

Moore, Tamson V; Scurti, Gina M; DeJong, Matthew; Wang, Siao-Yi; Dalheim, Annika V; Wagner, Courtney R; Hutchens, Kelli A; Speiser, Jodi J; Godellas, Constantine V; Fountain, Chris; Fleser, Jessica; Moudgil, Tarsem; Thomas, Mallory; Murray, David; Curti, Brendan D; Clark, Joseph I; Fox, Bernard A; Nishimura, Michael I.

Afiliación

Moore TV; Department of Surgery, Loyola University Chicago, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
Scurti GM; Department of Surgery, Loyola University Chicago, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
DeJong M; Department of Surgery, Loyola University Chicago, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
Wang SY; Department of Medicine, Loyola University Chicago, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
Dalheim AV; Department of Surgery, Loyola University Chicago, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
Wagner CR; Department of Medicine, Loyola University Chicago, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
Hutchens KA; Department of Pathology, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
Speiser JJ; Department of Pathology, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
Godellas CV; Department of Surgery, Loyola University Chicago, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
Fountain C; Providence Cancer Center Clinical Trials-Melanoma and Brain Cancer, 4805 Northeast Glisan Street, Portland, OR 97213, USA.
Fleser J; Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Portland, OR 97213, USA.
Moudgil T; Laboratory of Molecular and Tumor Immunology, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR 97213, USA.
Thomas M; Department of Surgery, Loyola University Chicago, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
Murray D; Department of Surgery, Loyola University Chicago, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
Curti BD; Laboratory of Molecular and Tumor Immunology, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR 97213, USA.
Clark JI; Department of Medicine, Loyola University Chicago, 2160 S. 1st Avenue, Maywood, IL 60153, USA.
Fox BA; Laboratory of Molecular and Tumor Immunology, Robert W. Franz Cancer Research Center, Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR 97213, USA.
Nishimura MI; Department of Molecular Microbiology and Immunology and Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97210, USA.

Mol Ther Oncolytics ; 20: 352-363, 2021 Mar 26.

Article en En | MEDLINE | ID: mdl-33614916

Palabras clave

HDAC inhibitors; TCR-transduced T cells; cancer immunotherapy; cell therapy; functional responses; gene silencing; gene-modified T cells; sodium butyrate; transgene silencing; vorinostat

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