Efficient G protein coupling is not required for agonist-mediated internalization and membrane reorganization of the adenosine A<sub>3</sub> receptor.

Stoddart, Leigh A; Kilpatrick, Laura E; Corriden, Ross; Kellam, Barrie; Briddon, Stephen J; Hill, Stephen J

Efficient G protein coupling is not required for agonist-mediated internalization and membrane reorganization of the adenosine A₃ receptor.

Stoddart, Leigh A; Kilpatrick, Laura E; Corriden, Ross; Kellam, Barrie; Briddon, Stephen J; Hill, Stephen J.

Afiliación

Stoddart LA; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.
Kilpatrick LE; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, UK.
Corriden R; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.
Kellam B; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, UK.
Briddon SJ; School of Pharmacy, Biodiscovery Institute, University Park Nottingham, Nottingham, UK.
Hill SJ; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.

FASEB J ; 35(4): e21211, 2021 04.

Article en En | MEDLINE | ID: mdl-33710641

Asunto(s)

Agonistas del Receptor de Adenosina A3/farmacología; Adenosina/análogos & derivados; Compuestos de Boro/farmacología; Proteínas de Unión al GTP/metabolismo; Receptor de Adenosina A3/metabolismo; Adenosina/farmacología; Animales; Arrestina/metabolismo; Células CHO; Cricetulus; Regulación de la Expresión Génica/efectos de los fármacos; Mutación; Unión Proteica; Receptor de Adenosina A3/genética

Palabras clave

G protein-coupled receptor; adenosine A3 receptor; fluorescence correlation spectroscopy; internalization; membrane organization; ß-arrestin

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Compuestos de Boro / Adenosina / Proteínas de Unión al GTP / Receptor de Adenosina A3 / Agonistas del Receptor de Adenosina A3 Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2021 Tipo del documento: Article

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