Morroniside protects OLN-93 cells against H<sub>2</sub>O<sub>2</sub>-induced injury through the PI3K/Akt pathway-mediated antioxidative stress and antiapoptotic activities.

Li, Fengzhi; Song, Xue; Xu, Jiaxin; Shi, Yujiao; Hu, Ruina; Ren, Zhen; Qi, Qi; Lü, Hezuo; Cheng, Xiaoxin; Hu, Jianguo

Morroniside protects OLN-93 cells against H₂O₂-induced injury through the PI3K/Akt pathway-mediated antioxidative stress and antiapoptotic activities.

Li, Fengzhi; Song, Xue; Xu, Jiaxin; Shi, Yujiao; Hu, Ruina; Ren, Zhen; Qi, Qi; Lü, Hezuo; Cheng, Xiaoxin; Hu, Jianguo.

Afiliación

Li F; Department of Cell Biology College of Basic Medical Sciences, Dalian Medical University, Dalian, P.R. China.
Song X; Department of Central Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China.
Xu J; Department of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China.
Shi Y; Department of Cell Biology College of Basic Medical Sciences, Dalian Medical University, Dalian, P.R. China.
Hu R; Department of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China.
Ren Z; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, P.R. China.
Qi Q; Department of Cell Biology College of Basic Medical Sciences, Dalian Medical University, Dalian, P.R. China.
Lü H; Department of Cell Biology College of Basic Medical Sciences, Dalian Medical University, Dalian, P.R. China.
Cheng X; Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, P.R. China.
Hu J; Department of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, P.R. China.

Cell Cycle ; 20(7): 661-675, 2021 04.

Article en En | MEDLINE | ID: mdl-33734020

Asunto(s)

Glicósidos/farmacología; Peróxido de Hidrógeno/toxicidad; Oligodendroglía/metabolismo; Estrés Oxidativo/fisiología; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Animales; Apoptosis/efectos de los fármacos; Apoptosis/fisiología; Línea Celular; Supervivencia Celular/efectos de los fármacos; Supervivencia Celular/fisiología; Citoprotección/efectos de los fármacos; Citoprotección/fisiología; Relación Dosis-Respuesta a Droga; Oligodendroglía/efectos de los fármacos; Estrés Oxidativo/efectos de los fármacos; Ratas; Transducción de Señal/efectos de los fármacos; Transducción de Señal/fisiología

Palabras clave

H2O2; Morroniside; OLN-93 cells; PI3K/Akt; antiapoptotic activities; antioxidative stress

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Oligodendroglía / Estrés Oxidativo / Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt / Glicósidos / Peróxido de Hidrógeno Idioma: En Revista: Cell Cycle Año: 2021 Tipo del documento: Article

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