Discovery of sertraline and its derivatives able to combat drug-resistant gastric cancer cell via inducing apoptosis.

Mu, Chao; Peng, Rui-Kun; Guo, Chun-Ling; Li, Ao; Yang, Xiu-Ming; Zeng, Rong; Li, Yu-Long; Gu, Jing; Ouyang, Qin

Mu, Chao; Peng, Rui-Kun; Guo, Chun-Ling; Li, Ao; Yang, Xiu-Ming; Zeng, Rong; Li, Yu-Long; Gu, Jing; Ouyang, Qin.

Afiliación

Mu C; College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong 643000, China.
Peng RK; Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, Chongqing 40038, China.
Guo CL; Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, Chongqing 40038, China.
Li A; College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong 643000, China.
Yang XM; Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, Chongqing 40038, China.
Zeng R; Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, Chongqing 40038, China.
Li YL; College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong 643000, China. Electronic address: yu_longli@aliyun.com.
Gu J; Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, Chongqing 40038, China. Electronic address: gujing_1020@126.com.
Ouyang Q; Department of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, Chongqing 40038, China. Electronic address: ouyangq@tmmu.edu.cn.

Bioorg Med Chem Lett ; 41: 127997, 2021 06 01.

Article en En | MEDLINE | ID: mdl-33775839

Asunto(s)

Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Descubrimiento de Drogas; Resistencia a Antineoplásicos/efectos de los fármacos; Sertralina/farmacología; Neoplasias Gástricas/tratamiento farmacológico; Antineoplásicos/síntesis química; Antineoplásicos/química; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Relación Dosis-Respuesta a Droga; Ensayos de Selección de Medicamentos Antitumorales; Humanos; Estructura Molecular; Sertralina/síntesis química; Sertralina/química; Neoplasias Gástricas/metabolismo; Neoplasias Gástricas/patología; Relación Estructura-Actividad

Palabras clave

Apoptosis; Chemosensitizer; Drug-resistant; Gastric cancer; Sertraline

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Apoptosis / Resistencia a Antineoplásicos / Sertralina / Descubrimiento de Drogas / Antineoplásicos Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article

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