Pharmacological treatment of nonresponders following bariatric surgery: a narrative review of the current evidence.
Minerva Endocrinol (Torino)
; 2021 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-33792233
ABSTRACT
INTRODUCTION:
Obesity is a complex chronic disease and requires a long-term multidisciplinary management. Even patients undergoing bariatric surgery, one the most effective treatments for obesity, can have insufficient weight loss (IWL) than expected (primary non responder) or weight regain (WR) after a successful primary procedure (secondary non responder). A poor response represents a challenge of bariatric surgery that can induce persistence or recurrence of obesity-related comorbidities, prejudicing benefits of surgery. Increasing evidence suggests that weight loss medications represent a useful strategy in obesity care also after bariatric surgery procedures. EVIDENCE ACQUISITION This narrative review summarizes the evidence concerning anti-obesity therapy in the management of no-responders to primary bariatric surgery. Available data on liraglutide (one randomized double-blind placebo-controlled trial, three prospective and three retrospective studies), naltrexone/bupropion (three retrospective studies), orlistat (one case control prospective and one retrospective studies) and topiramate and phentermine (5 retrospective studies) have been considered. EVIDENCESYNTHESIS:
Available data suggest that weight loss medications could offer a significant adjunctive benefit to lifestyle and behavioral modifications in the life-long management of obesity.CONCLUSIONS:
Newer treatment modalities including the use of anti-obesity drugs provide patients and healthcare providers with more options in the management of poor response after bariatric surgery.
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MEDLINE
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Clinical_trials
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Observational_studies
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En
Revista:
Minerva Endocrinol (Torino)
Año:
2021
Tipo del documento:
Article