Hyposialylation Must Be Considered to Develop Future Therapies in Autoimmune Diseases.
Int J Mol Sci
; 22(7)2021 Mar 26.
Article
en En
| MEDLINE
| ID: mdl-33810246
ABSTRACT
Autoimmune disease development depends on multiple factors, including genetic and environmental. Abnormalities such as sialylation levels and/or quality have been recently highlighted. The adjunction of sialic acid at the terminal end of glycoproteins and glycolipids is essential for distinguishing between self and non-self-antigens and the control of pro- or anti-inflammatory immune reactions. In autoimmunity, hyposialylation is responsible for chronic inflammation, the anarchic activation of the immune system and organ lesions. A detailed characterization of this mechanism is a key element for improving the understanding of these diseases and the development of innovative therapies. This review focuses on the impact of sialylation in autoimmunity in order to determine future treatments based on the regulation of hyposialylation.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ácidos Siálicos
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Autoanticuerpos
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Enfermedades Autoinmunes
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Procesamiento Proteico-Postraduccional
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Int J Mol Sci
Año:
2021
Tipo del documento:
Article