Urchin-like Hydroxyapatite/Graphene Hollow Microspheres as pH-Responsive Bone Drug Carriers.
Langmuir
; 37(14): 4137-4146, 2021 04 13.
Article
en En
| MEDLINE
| ID: mdl-33813823
ABSTRACT
Hydroxyapatite (HA) is the main inorganic component of human bones and teeth. It has good biocompatibility and bioactivity, which promotes its good application prospects in the field of bone drug carriers. In this study, tetraethylenepentamine-graphene (rGO-TEPA)/CaCO3HA composite microspheres were prepared via microwave hydrothermal synthesis using rGO-TEPA/CaCO3 solid microspheres as intermediates. Furthermore, the incompletely transformed CaCO3 was removed by soaking in a citric acid buffer to obtain rGO-TEPA/HA hollow composite microspheres. The two types of as-prepared composite microspheres exhibited sea urchin-like structures, large BET surface areas, and good dispersibility. Mouse preosteoblast cells (MC3T3-E1) were used for in vitro cytotoxicity experiments. The in vitro cell viability test showed that the two composite drug carriers exhibited noncytotoxicity. Moreover, the doxorubicin (DOX) loading and releasing investigations revealed that the two types of prepared carriers had mild storage-release behaviors and good pH responsiveness. Hence, these rGO-TEPA/HA hollow microspheres have promising applications as bone drug carriers.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Erizos de Mar
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Huesos
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Portadores de Fármacos
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Durapatita
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Materiales Biomiméticos
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Grafito
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Microesferas
Idioma:
En
Revista:
Langmuir
Asunto de la revista:
QUIMICA
Año:
2021
Tipo del documento:
Article