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Simple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacy.
Gürses, Tugba; Olgaç, Abdurrahman; Garscha, Ulrike; Gür Maz, Tugçe; Bal, Nur Banu; Uludag, Orhan; Çaliskan, Burcu; Schubert, Ulrich S; Werz, Oliver; Banoglu, Erden.
Afiliación
  • Gürses T; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey.
  • Olgaç A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey.
  • Garscha U; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, D-7743 Jena, Germany.
  • Gür Maz T; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey.
  • Bal NB; Department of Pharmacology, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey.
  • Uludag O; Department of Pharmacology, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey.
  • Çaliskan B; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey.
  • Schubert US; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany; Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstrasse 10, D-07743 Jena, Germany.
  • Werz O; Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Friedrich-Schiller-University Jena, Philosophenweg 14, D-7743 Jena, Germany; Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743 Jena, Germany.
  • Banoglu E; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Yenimahalle, 06560 Ankara, Turkey. Electronic address: banoglu@gazi.edu.tr.
Bioorg Chem ; 112: 104861, 2021 07.
Article en En | MEDLINE | ID: mdl-33826984
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Araquidonato 5-Lipooxigenasa / Ácidos Carboxílicos / Inhibidores Enzimáticos / Prostaglandina-E Sintasas / Androstenoles Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Araquidonato 5-Lipooxigenasa / Ácidos Carboxílicos / Inhibidores Enzimáticos / Prostaglandina-E Sintasas / Androstenoles Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article