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Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease.
Hamulakova, Slavka; Kudlickova, Zuzana; Janovec, Ladislav; Mezencev, Roman; Deckner, Zachery J; Chernoff, Yury O; Janockova, Jana; Ihnatova, Veronika; Bzonek, Petr; Novakova, Nikola; Hepnarova, Vendula; Hrabinova, Martina; Jun, Daniel; Korabecny, Jan; Soukup, Ondrej; Kuca, Kamil.
Afiliación
  • Hamulakova S; Department of Organic Chemistry, Institute of Chemical Sciences, Faculty of Science, PJ Safarik University, Moyzesova 11, Kosice, SK-041 67, Slovak Republic.
  • Kudlickova Z; Department of Chemistry, Biochemistry & Biophysics, University of Veterinary Medicine & Pharmacy, Komenského 73, Kosice, 041 81, Slovak Republic.
  • Janovec L; Department of Organic Chemistry, Institute of Chemical Sciences, Faculty of Science, PJ Safarik University, Moyzesova 11, Kosice, SK-041 67, Slovak Republic.
  • Mezencev R; School of Biological Sciences, Georgia Institute of Technology, Krone Engineered Biosystems Building, 950 Atlantic Drive NW, Atlanta, GA 30332-2000, USA.
  • Deckner ZJ; School of Biological Sciences, Georgia Institute of Technology, Krone Engineered Biosystems Building, 950 Atlantic Drive NW, Atlanta, GA 30332-2000, USA.
  • Chernoff YO; School of Biological Sciences, Georgia Institute of Technology, Krone Engineered Biosystems Building, 950 Atlantic Drive NW, Atlanta, GA 30332-2000, USA.
  • Janockova J; Laboratory of Amyloid Biology, St. Petersburg State University, St. Petersburg, 199034, Russia.
  • Ihnatova V; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove, 500 05, Czech Republic.
  • Bzonek P; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove, 500 05, Czech Republic.
  • Novakova N; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove, 500 05, Czech Republic.
  • Hepnarova V; Department of Toxicology & Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesska 1575, Hradec Kralove, 500 05, Czech Republic.
  • Hrabinova M; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove, 500 05, Czech Republic.
  • Jun D; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove, 500 05, Czech Republic.
  • Korabecny J; Department of Toxicology & Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesska 1575, Hradec Kralove, 500 05, Czech Republic.
  • Soukup O; Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove, 500 05, Czech Republic.
  • Kuca K; Department of Toxicology & Military Pharmacy, Faculty of Military Health Sciences, University of Defense, Trebesska 1575, Hradec Kralove, 500 05, Czech Republic.
Future Med Chem ; 13(9): 785-804, 2021 05.
Article en En | MEDLINE | ID: mdl-33829876
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Acetilcolinesterasa / Tacrina / Inhibidores de la Colinesterasa / Péptidos beta-Amiloides / Fármacos Neuroprotectores / Enfermedad de Alzheimer / Indoles Idioma: En Revista: Future Med Chem Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Acetilcolinesterasa / Tacrina / Inhibidores de la Colinesterasa / Péptidos beta-Amiloides / Fármacos Neuroprotectores / Enfermedad de Alzheimer / Indoles Idioma: En Revista: Future Med Chem Año: 2021 Tipo del documento: Article