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Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia.
Wang, Chao; Xiong, Monica; Gratuze, Maud; Bao, Xin; Shi, Yang; Andhey, Prabhakar Sairam; Manis, Melissa; Schroeder, Caitlin; Yin, Zhuoran; Madore, Charlotte; Butovsky, Oleg; Artyomov, Maxim; Ulrich, Jason D; Holtzman, David M.
Afiliación
  • Wang C; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease, Research Center, Washington University, St. Louis, MO 63110, USA.
  • Xiong M; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease, Research Center, Washington University, St. Louis, MO 63110, USA.
  • Gratuze M; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease, Research Center, Washington University, St. Louis, MO 63110, USA.
  • Bao X; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease, Research Center, Washington University, St. Louis, MO 63110, USA.
  • Shi Y; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease, Research Center, Washington University, St. Louis, MO 63110, USA.
  • Andhey PS; Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.
  • Manis M; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease, Research Center, Washington University, St. Louis, MO 63110, USA.
  • Schroeder C; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Yin Z; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Madore C; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Butovsky O; Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Evergrande Center for Immunologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Artyomov M; Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.
  • Ulrich JD; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease, Research Center, Washington University, St. Louis, MO 63110, USA. Electronic address: ulrichjd@wustl.edu.
  • Holtzman DM; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer Disease, Research Center, Washington University, St. Louis, MO 63110, USA. Electronic address: holtzman@wustl.edu.
Neuron ; 109(10): 1657-1674.e7, 2021 05 19.
Article en En | MEDLINE | ID: mdl-33831349
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fagocitosis / Astrocitos / Tauopatías / Apolipoproteína E4 Tipo de estudio: Risk_factors_studies Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fagocitosis / Astrocitos / Tauopatías / Apolipoproteína E4 Tipo de estudio: Risk_factors_studies Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article