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Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels.
Shao, Hao; Li, Xiaokai; Hayashi, Shigenari; Bertron, Jeanette L; Schwarz, Daniel M C; Tang, Benjamin C; Gestwicki, Jason E.
Afiliación
  • Shao H; Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Electronic address: haoshaodream@hotmail.com.
  • Li X; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, United States; Institute for Neurodegenerative Disease, University of California San Francisco, San Francisco, CA 94158, United States.
  • Hayashi S; Institute for Neurodegenerative Disease, University of California San Francisco, San Francisco, CA 94158, United States.
  • Bertron JL; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, United States; Institute for Neurodegenerative Disease, University of California San Francisco, San Francisco, CA 94158, United States.
  • Schwarz DMC; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, United States; Institute for Neurodegenerative Disease, University of California San Francisco, San Francisco, CA 94158, United States.
  • Tang BC; Institute for Neurodegenerative Disease, University of California San Francisco, San Francisco, CA 94158, United States.
  • Gestwicki JE; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, United States; Institute for Neurodegenerative Disease, University of California San Francisco, San Francisco, CA 94158, United States. Electronic address: Jason.gestwicki@ucsf.edu.
Bioorg Med Chem Lett ; 41: 128025, 2021 06 01.
Article en En | MEDLINE | ID: mdl-33839251
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas tau / Proteínas HSP70 de Choque Térmico / Benzotiazoles / Tiazolidinas Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas tau / Proteínas HSP70 de Choque Térmico / Benzotiazoles / Tiazolidinas Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article