Classification Criteria for Varicella Zoster Virus Anterior Uveitis.
Am J Ophthalmol
; 228: 165-173, 2021 08.
Article
en En
| MEDLINE
| ID: mdl-33845010
ABSTRACT
PURPOSE:
To determine classification criteria for varicella zoster virus (VZV) anterior uveitis.DESIGN:
Machine learning of cases with VZV anterior uveitis and 8 other anterior uveitides.METHODS:
Cases of anterior uveitides were collected in an informatics-designed preliminary database, and a final database was constructed of cases achieving supermajority agreement on the diagnosis, using formal consensus techniques. Cases were split into a training set and a validation set. Machine learning using multinomial logistic regression was used on the training set to determine a parsimonious set of criteria that minimized the misclassification rate among the anterior uveitides. The resulting criteria were evaluated on the validation set.RESULTS:
One thousand eighty-three cases of anterior uveitides, including 123 cases of VZV anterior uveitis, were evaluated by machine learning. The overall accuracy for anterior uveitides was 97.5% in the training set and 96.7% in the validation set (95% confidence interval 92.4, 98.6). Key criteria for VZV anterior uveitis included unilateral anterior uveitis with either (1) positive aqueous humor polymerase chain reaction assay for VZV; (2) sectoral iris atrophy in a patient ≥60 years of age; or (3) concurrent or recent dermatomal herpes zoster. The misclassification rates for VZV anterior uveitis were 0.9% in the training set and 0% in the validation set, respectively.CONCLUSIONS:
The criteria for VZV anterior uveitis had a low misclassification rate and seemed to perform sufficiently well for use in clinical and translational research.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Humor Acuoso
/
ADN Viral
/
Infecciones Virales del Ojo
/
Uveítis Anterior
/
Herpes Zóster Oftálmico
/
Herpesvirus Humano 3
/
Aprendizaje Automático
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Am J Ophthalmol
Año:
2021
Tipo del documento:
Article