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mRNA vaccination compared to infection elicits an IgG-predominant response with greater SARS-CoV-2 specificity and similar decrease in variant spike recognition.
Röltgen, Katharina; Nielsen, Sandra C A; Arunachalam, Prabhu S; Yang, Fan; Hoh, Ramona A; Wirz, Oliver F; Lee, Alexandra S; Gao, Fei; Mallajosyula, Vamsee; Li, Chunfeng; Haraguchi, Emily; Shoura, Massa J; Wilbur, James L; Wohlstadter, Jacob N; Davis, Mark M; Pinsky, Benjamin A; Sigal, George B; Pulendran, Bali; Nadeau, Kari C; Boyd, Scott D.
Afiliación
  • Röltgen K; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Nielsen SCA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Arunachalam PS; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
  • Yang F; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Hoh RA; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Wirz OF; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Lee AS; Sean N. Parker Center for Allergy & Asthma Research, Stanford, CA, USA.
  • Gao F; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
  • Mallajosyula V; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
  • Li C; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
  • Haraguchi E; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Shoura MJ; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Wilbur JL; Meso Scale Diagnostics LLC, Rockville, Maryland, USA.
  • Wohlstadter JN; Meso Scale Diagnostics LLC, Rockville, Maryland, USA.
  • Davis MM; Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
  • Pinsky BA; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.
  • Sigal GB; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.
  • Pulendran B; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
  • Nadeau KC; Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA USA.
  • Boyd SD; Meso Scale Diagnostics LLC, Rockville, Maryland, USA.
medRxiv ; 2021 Apr 07.
Article en En | MEDLINE | ID: mdl-33851181
ABSTRACT
During the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, new vaccine strategies including lipid nanoparticle delivery of antigen encoding RNA have been deployed globally. The BioNTech/Pfizer mRNA vaccine BNT162b2 encoding SARS-CoV-2 spike protein shows 95% efficacy in preventing disease, but it is unclear how the antibody responses to vaccination differ from those generated by infection. Here we compare the magnitude and breadth of antibodies targeting SARS-CoV-2, SARS-CoV-2 variants of concern, and endemic coronaviruses, in vaccinees and infected patients. We find that vaccination differs from infection in the dominance of IgG over IgM and IgA responses, with IgG reaching levels similar to those of severely ill COVID-19 patients and shows decreased breadth of the antibody response targeting endemic coronaviruses. Viral variants of concern from B.1.1.7 to P.1 to B.1.351 form a remarkably consistent hierarchy of progressively decreasing antibody recognition by both vaccinees and infected patients exposed to Wuhan-Hu-1 antigens.
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: MedRxiv Año: 2021 Tipo del documento: Article