Pyrazoles as novel protein tyrosine phosphatase 1B (PTP1B) inhibitors: An in vitro and in silico study.

Rocha, Sónia; Lucas, Mariana; Silva, Vera L M; Gomes, Pedro M O; Silva, Artur M S; Araújo, Alberto N; Aniceto, Natália; Guedes, Rita C; Corvo, M Luísa; Fernandes, Eduarda; Freitas, Marisa

Rocha, Sónia; Lucas, Mariana; Silva, Vera L M; Gomes, Pedro M O; Silva, Artur M S; Araújo, Alberto N; Aniceto, Natália; Guedes, Rita C; Corvo, M Luísa; Fernandes, Eduarda; Freitas, Marisa.

Afiliación

Rocha S; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Lucas M; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Silva VLM; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Gomes PMO; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Silva AMS; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Araújo AN; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
Aniceto N; Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.
Guedes RC; Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.
Corvo ML; Research Institute for Medicines, Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal.
Fernandes E; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address: egracas@ff.up.pt.
Freitas M; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address: marisafreitas@ff.up.pt.

Int J Biol Macromol ; 181: 1171-1182, 2021 Jun 30.

Article en En | MEDLINE | ID: mdl-33857515

Asunto(s)

Diabetes Mellitus Tipo 2/tratamiento farmacológico; Inhibidores Enzimáticos/farmacología; Proteína Tirosina Fosfatasa no Receptora Tipo 1/genética; Pirazoles/farmacología; Sitios de Unión/efectos de los fármacos; Simulación por Computador; Diabetes Mellitus Tipo 2/genética; Diabetes Mellitus Tipo 2/metabolismo; Inhibidores Enzimáticos/química; Humanos; Insulina/química; Insulina/genética; Insulina/metabolismo; Resistencia a la Insulina/genética; Simulación del Acoplamiento Molecular; Proteína Tirosina Fosfatasa no Receptora Tipo 1/antagonistas & inhibidores; Proteína Tirosina Fosfatasa no Receptora Tipo 1/química; Proteína Tirosina Fosfatasa no Receptora Tipo 2/genética; Transducción de Señal/efectos de los fármacos

Palabras clave

Diabetes; Insulin resistance; Insulin signaling; Protein tyrosine phosphatase 1B; Pyrazoles; Synthetic inhibitors; T-cell protein tyrosine phosphatase

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pirazoles / Diabetes Mellitus Tipo 2 / Inhibidores Enzimáticos / Proteína Tirosina Fosfatasa no Receptora Tipo 1 Tipo de estudio: Prognostic_studies Idioma: En Revista: Int J Biol Macromol Año: 2021 Tipo del documento: Article

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