Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury.

Cao, Jing-Yuan; Wang, Bin; Tang, Tao-Tao; Wen, Yi; Li, Zuo-Lin; Feng, Song-Tao; Wu, Min; Liu, Dan; Yin, Di; Ma, Kun-Ling; Tang, Ri-Ning; Wu, Qiu-Li; Lan, Hui-Yao; Lv, Lin-Li; Liu, Bi-Cheng

Cao, Jing-Yuan; Wang, Bin; Tang, Tao-Tao; Wen, Yi; Li, Zuo-Lin; Feng, Song-Tao; Wu, Min; Liu, Dan; Yin, Di; Ma, Kun-Ling; Tang, Ri-Ning; Wu, Qiu-Li; Lan, Hui-Yao; Lv, Lin-Li; Liu, Bi-Cheng.

Afiliación

Cao JY; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.
Wang B; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.
Tang TT; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.
Wen Y; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.
Li ZL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.
Feng ST; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.
Wu M; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.
Liu D; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.
Yin D; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.
Ma KL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.
Tang RN; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.
Wu QL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.
Lan HY; Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Liu Che Woo Institute of Innovative Medicine, Chinese University of Hong Kong, Hong Kong SAR 999077, China.
Lv LL; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.
Liu BC; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing 210009, China.

Theranostics ; 11(11): 5248-5266, 2021.

Article en En | MEDLINE | ID: mdl-33859745

Asunto(s)

Lesión Renal Aguda/genética; Exosomas/genética; Túbulos Renales Proximales/fisiología; Células Madre Mesenquimatosas/fisiología; MicroARNs/genética; Daño por Reperfusión/genética; Proteína p53 Supresora de Tumor/genética; Lesión Renal Aguda/fisiopatología; Animales; Apoptosis/genética; Proteína Quinasa CDC2/genética; Puntos de Control del Ciclo Celular/genética; División Celular/genética; Línea Celular; Proliferación Celular/genética; Ciclina B1/genética; Células Epiteliales/fisiología; Fase G2/genética; Humanos; Isquemia/genética; Isquemia/fisiopatología; Masculino; Ratones; Ratones Endogámicos C57BL; Proteínas Proto-Oncogénicas c-bcl-2/genética; Daño por Reperfusión/fisiopatología; Distribución Tisular/genética; Proteína X Asociada a bcl-2/genética

Palabras clave

acute kidney injury; exosomes; mesenchymal stem cell; miR-125b-5p; tubular repair

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Daño por Reperfusión / Proteína p53 Supresora de Tumor / MicroARNs / Exosomas / Lesión Renal Aguda / Células Madre Mesenquimatosas / Túbulos Renales Proximales Idioma: En Revista: Theranostics Año: 2021 Tipo del documento: Article

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