Suppression of NLRP3 inflammasome by Platycodin D via the TLR4/MyD88/NF-&#954;B pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats.

Wu, Yongcan; Huang, Demei; Wang, Xiaomin; Pei, Caixia; Xiao, Wei; Wang, Fei; Wang, Zhenxing

Suppression of NLRP3 inflammasome by Platycodin D via the TLR4/MyD88/NF-κB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats.

Wu, Yongcan; Huang, Demei; Wang, Xiaomin; Pei, Caixia; Xiao, Wei; Wang, Fei; Wang, Zhenxing.

Afiliación

Wu Y; Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, People's Republic of China.
Huang D; Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, People's Republic of China.
Wang X; Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, People's Republic of China.
Pei C; Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, People's Republic of China.
Xiao W; Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, People's Republic of China.
Wang F; Department of Geriatrics, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, People's Republic of China. Electronic address: wangfei896@163.com.
Wang Z; Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shi-er-qiao Road, Chengdu 610072, Sichuan Province, People's Republic of China. Electronic address: wangzhenxing@vip.tom.com.

Int Immunopharmacol ; 96: 107621, 2021 Jul.

Article en En | MEDLINE | ID: mdl-33872850

Asunto(s)

Lesión Pulmonar Aguda/tratamiento farmacológico; Lesión Pulmonar Aguda/metabolismo; Factor 88 de Diferenciación Mieloide/metabolismo; FN-kappa B/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/antagonistas & inhibidores; Saponinas/farmacología; Receptor Toll-Like 4/metabolismo; Triterpenos/farmacología; Lesión Pulmonar Aguda/inducido químicamente; Lesión Pulmonar Aguda/patología; Animales; Proteínas Reguladoras de la Apoptosis/metabolismo; Caspasa 1/metabolismo; Citocinas/genética; Citocinas/metabolismo; Regulación hacia Abajo/efectos de los fármacos; Edema/inducido químicamente; Edema/tratamiento farmacológico; Proteínas I-kappa B/metabolismo; Inflamasomas; Lipopolisacáridos/toxicidad; Macrófagos Alveolares/ultraestructura; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Proteínas de Neoplasias/metabolismo; Proteínas de Transporte Nucleocitoplasmático/metabolismo; Tamaño de los Órganos/efectos de los fármacos; Estrés Oxidativo/efectos de los fármacos; Ratas Sprague-Dawley; Saponinas/uso terapéutico; Transducción de Señal/efectos de los fármacos; Triterpenos/uso terapéutico

Palabras clave

Acute lung injury; Lipopolysaccharide; NLRP3; Platycodin D; TLR4/MyD88/NF-κB

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Saponinas / Triterpenos / FN-kappa B / Receptor Toll-Like 4 / Factor 88 de Diferenciación Mieloide / Lesión Pulmonar Aguda / Proteína con Dominio Pirina 3 de la Familia NLR Idioma: En Revista: Int Immunopharmacol Asunto de la revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article

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