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Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl accident.
Yeager, Meredith; Machiela, Mitchell J; Kothiyal, Prachi; Dean, Michael; Bodelon, Clara; Suman, Shalabh; Wang, Mingyi; Mirabello, Lisa; Nelson, Chase W; Zhou, Weiyin; Palmer, Cameron; Ballew, Bari; Colli, Leandro M; Freedman, Neal D; Dagnall, Casey; Hutchinson, Amy; Vij, Vibha; Maruvka, Yosi; Hatch, Maureen; Illienko, Iryna; Belayev, Yuri; Nakamura, Nori; Chumak, Vadim; Bakhanova, Elena; Belyi, David; Kryuchkov, Victor; Golovanov, Ivan; Gudzenko, Natalia; Cahoon, Elizabeth K; Albert, Paul; Drozdovitch, Vladimir; Little, Mark P; Mabuchi, Kiyohiko; Stewart, Chip; Getz, Gad; Bazyka, Dimitry; Berrington de Gonzalez, Amy; Chanock, Stephen J.
Afiliación
  • Yeager M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA. chanocks@mail.nih.gov yeagerm@mail.nih.gov.
  • Machiela MJ; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  • Kothiyal P; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Dean M; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Bodelon C; SymbioSeq LLC, Arlington, VA 20148, USA.
  • Suman S; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Wang M; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  • Mirabello L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Nelson CW; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Zhou W; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  • Palmer C; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Ballew B; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  • Colli LM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Freedman ND; Biodiversity Research Center, Academia Sinica, Taipei, 11529, Taiwan.
  • Dagnall C; Institute for Comparative Genomics, American Museum of Natural History, New York, NY 10024, USA.
  • Hutchinson A; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Vij V; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  • Maruvka Y; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Hatch M; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  • Illienko I; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Belayev Y; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  • Nakamura N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Chumak V; Department of Medical Imaging, Hematology, and Oncology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, 14049-900, Brazil.
  • Bakhanova E; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Belyi D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Kryuchkov V; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  • Golovanov I; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Gudzenko N; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
  • Cahoon EK; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Albert P; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  • Drozdovitch V; Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Little MP; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA.
  • Mabuchi K; National Research Centre for Radiation Medicine, 53 Yu. Illienka Street, Kyiv, 04050, Ukraine.
  • Stewart C; National Research Centre for Radiation Medicine, 53 Yu. Illienka Street, Kyiv, 04050, Ukraine.
  • Getz G; Department of Molecular Biosciences, Radiation Effects Research Foundation, 5-2 Hijiyama Park, Minami-ku, Hiroshima, 732-0815, Japan.
  • Bazyka D; National Research Centre for Radiation Medicine, 53 Yu. Illienka Street, Kyiv, 04050, Ukraine.
  • Berrington de Gonzalez A; National Research Centre for Radiation Medicine, 53 Yu. Illienka Street, Kyiv, 04050, Ukraine.
  • Chanock SJ; National Research Centre for Radiation Medicine, 53 Yu. Illienka Street, Kyiv, 04050, Ukraine.
Science ; 372(6543): 725-729, 2021 05 14.
Article en En | MEDLINE | ID: mdl-33888597
ABSTRACT
Effects of radiation exposure from the Chernobyl nuclear accident remain a topic of interest. We investigated germline de novo mutations (DNMs) in children born to parents employed as cleanup workers or exposed to occupational and environmental ionizing radiation after the accident. Whole-genome sequencing of 130 children (born 1987-2002) and their parents did not reveal an increase in the rates, distributions, or types of DNMs relative to the results of previous studies. We find no elevation in total DNMs, regardless of cumulative preconception gonadal paternal [mean = 365 milligrays (mGy), range = 0 to 4080 mGy] or maternal (mean = 19 mGy, range = 0 to 550 mGy) exposure to ionizing radiation. Thus, we conclude that, over this exposure range, evidence is lacking for a substantial effect on germline DNMs in humans, suggesting minimal impact from transgenerational genetic effects.
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Science Año: 2021 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Science Año: 2021 Tipo del documento: Article