Determinants of Suboptimal Outcome Following Thymectomy in Myasthenia Gravis.
Neurol India
; 69(2): 419-425, 2021.
Article
en En
| MEDLINE
| ID: mdl-33904466
ABSTRACT
BACKGROUND:
Response to thymectomy in myasthenia gravis (MG) is influenced by various patient-, disease-, and therapy-related factors.METHODS:
Retrospective analysis of 128 patients with MG who underwent maximal thymectomy over 15 years was done to identify the determinants of suboptimal clinical outcome.RESULTS:
Among the 128 patients, 62 (48.4%) were females with a mean age of 38.97 (12.29) years. Thymomatous MG occurred in 66 (51.6%). Overall improvement from preoperative status was noted in 88 (68.8%) patients after mean follow-up of 51.68 (33.21) months. The presence of thymoma was the major predictor of suboptimal clinical outcome (P = 0.001), whereas age, gender, preoperative disease severity, and seropositive status did not attain significance. Patients with better outcome had received higher steroid dose preoperatively (P = 0.035).CONCLUSIONS:
Suboptimal response after thymectomy occurred in one-third of MG patients, more commonly with thymomatous MG. Relationship of preoperative steroid therapy to remission merits evaluation.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Timoma
/
Neoplasias del Timo
/
Miastenia Gravis
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Neurol India
Año:
2021
Tipo del documento:
Article