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The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Asanovic, Igor; Strandback, Emilia; Kroupova, Alena; Pasajlic, Djurdja; Meinhart, Anton; Tsung-Pin, Pai; Djokovic, Nemanja; Anrather, Dorothea; Schuetz, Thomas; Suskiewicz, Marcin Józef; Sillamaa, Sirelin; Köcher, Thomas; Beveridge, Rebecca; Nikolic, Katarina; Schleiffer, Alexander; Jinek, Martin; Hartl, Markus; Clausen, Tim; Penninger, Josef; Macheroux, Peter; Weitzer, Stefan; Martinez, Javier.
Afiliación
  • Asanovic I; Max Perutz Labs, Medical University of Vienna, Vienna BioCenter (VBC), Dr. Bohr-Gasse 9/2, 1030 Vienna, Austria.
  • Strandback E; Institute of Biochemistry, Graz University of Technology, Petersgasse 12/2, 8010 Graz, Austria; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.
  • Kroupova A; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
  • Pasajlic D; Max Perutz Labs, Medical University of Vienna, Vienna BioCenter (VBC), Dr. Bohr-Gasse 9/2, 1030 Vienna, Austria.
  • Meinhart A; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Campus-Vienna-BioCenter 1, 1030 Vienna, Austria.
  • Tsung-Pin P; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria; AnnJi Pharmaceutical, Taipei, Taiwan.
  • Djokovic N; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
  • Anrather D; Max Perutz Labs, University of Vienna, Vienna BioCenter (VBC), Dr. Bohr-Gasse 9, 1030 Vienna, Austria.
  • Schuetz T; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria; Department of Internal Medicine III (Cardiology and Angiology), Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
  • Suskiewicz MJ; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Campus-Vienna-BioCenter 1, 1030 Vienna, Austria; Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE Oxford, UK.
  • Sillamaa S; Institute of Molecular and Cell Biology, University of Tartu, Riia 23, 51010 Tartu, Estonia.
  • Köcher T; Vienna BioCenter Core Facilities, Campus-Vienna-BioCenter 1, 1030 Vienna, Austria.
  • Beveridge R; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Campus-Vienna-BioCenter 1, 1030 Vienna, Austria; Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, G1 1XL Glasgow, UK.
  • Nikolic K; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
  • Schleiffer A; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Campus-Vienna-BioCenter 1, 1030 Vienna, Austria; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria.
  • Jinek M; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
  • Hartl M; Max Perutz Labs, University of Vienna, Vienna BioCenter (VBC), Dr. Bohr-Gasse 9, 1030 Vienna, Austria.
  • Clausen T; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Campus-Vienna-BioCenter 1, 1030 Vienna, Austria.
  • Penninger J; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria; Department of Medical Genetics, Life Science Institute, University of British Columbia, C201 - 4500 Oak Street, V6H 3N1 Vancouver, BC, Canada.
  • Macheroux P; Institute of Biochemistry, Graz University of Technology, Petersgasse 12/2, 8010 Graz, Austria.
  • Weitzer S; Max Perutz Labs, Medical University of Vienna, Vienna BioCenter (VBC), Dr. Bohr-Gasse 9/2, 1030 Vienna, Austria. Electronic address: stefan.weitzer@meduniwien.ac.at.
  • Martinez J; Max Perutz Labs, Medical University of Vienna, Vienna BioCenter (VBC), Dr. Bohr-Gasse 9/2, 1030 Vienna, Austria. Electronic address: javier.martinez@meduniwien.ac.at.
Mol Cell ; 81(12): 2520-2532.e16, 2021 06 17.
Article en En | MEDLINE | ID: mdl-33930333
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: ARN Ligasa (ATP) / ARN de Transferencia / Oxidorreductasas actuantes sobre Donantes de Grupos Sulfuro Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: ARN Ligasa (ATP) / ARN de Transferencia / Oxidorreductasas actuantes sobre Donantes de Grupos Sulfuro Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article