Macrophage activation in the lung during the progression of nitrogen mustard induced injury is associated with histone modifications and altered miRNA expression.

Venosa, Alessandro; Smith, L Cody; Gow, Andrew J; Zarbl, Helmut; Laskin, Jeffrey D; Laskin, Debra L

Venosa, Alessandro; Smith, L Cody; Gow, Andrew J; Zarbl, Helmut; Laskin, Jeffrey D; Laskin, Debra L.

Afiliación

Venosa A; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT 84112, USA.
Smith LC; Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, NJ 08854, USA.
Gow AJ; Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA.
Zarbl H; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA; Department of Environmental and Occupational Health and Justice, Rutgers University School of Public Health, Piscataway, NJ 08854, USA.
Laskin JD; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA; Department of Environmental and Occupational Health and Justice, Rutgers University School of Public Health, Piscataway, NJ 08854, USA.
Laskin DL; Department of Pharmacology and Toxicology, Rutgers University Ernest Mario School of Pharmacy, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: laskin@eohsi.rutgers.edu.

Toxicol Appl Pharmacol ; 423: 115569, 2021 07 15.

Article en En | MEDLINE | ID: mdl-33971176

Asunto(s)

Lesión Pulmonar Aguda/inducido químicamente; Lesión Pulmonar Aguda/metabolismo; Histonas/biosíntesis; Activación de Macrófagos/efectos de los fármacos; Mecloretamina/toxicidad; MicroARNs/biosíntesis; Lesión Pulmonar Aguda/genética; Lesión Pulmonar Aguda/patología; Animales; Expresión Génica; Histonas/genética; Pulmón/efectos de los fármacos; Pulmón/metabolismo; Pulmón/patología; Activación de Macrófagos/fisiología; Masculino; Ratones; MicroARNs/genética; Ratas; Ratas Wistar

Palabras clave

Epigenetics; Histones; Lung; Macrophages; Nitrogen mustard; miRNAs

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Histonas / MicroARNs / Lesión Pulmonar Aguda / Activación de Macrófagos / Mecloretamina Tipo de estudio: Risk_factors_studies Idioma: En Revista: Toxicol Appl Pharmacol Año: 2021 Tipo del documento: Article

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